2024
Disease burden of cardiovascular conditions complicating pregnancy in Sri Lanka: a protocol
Hettiarachchi A, Lokunarangoda N, Agampodi T, Agampodi S. Disease burden of cardiovascular conditions complicating pregnancy in Sri Lanka: a protocol. F1000Research 2024, 10: 1028. PMID: 38504849, PMCID: PMC10948970, DOI: 10.12688/f1000research.52539.4.Peer-Reviewed Original ResearchCardiovascular diseasePeriod of amenorrhoeaBurden of CVDAdverse pregnancy outcomesEffects of CVDProspective cohort studyCardiovascular disease morbidityEvidence-based guidelinesRoutine clinical assessmentRisk prediction modelPostpartum morbidityPregnancy clinicWard admissionAntenatal careCohort studyPregnancy outcomesMaternal deathsMiddle-income countriesCVD burdenDisease morbidityEarly pregnancyFirst trimesterPregnant womenMaternal mortalityAppropriate referral
2023
Incorporating early pregnancy mental health screening and management into routine maternal care: experience from the Rajarata Pregnancy Cohort (RaPCo), Sri Lanka
Agampodi T, Amarasinghe G, Wickramasinghe A, Wickramasinghe N, Warnasekara J, Jayasinghe I, Hettiarachchi A, Nimesha D, Dilshani T, Senadheera S, Agampodi S. Incorporating early pregnancy mental health screening and management into routine maternal care: experience from the Rajarata Pregnancy Cohort (RaPCo), Sri Lanka. BMJ Global Health 2023, 8: e012852. PMID: 37748792, PMCID: PMC10533714, DOI: 10.1136/bmjgh-2023-012852.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScaleMental health screeningMental health problemsPregnancy cohortSecond trimesterEarly pregnancyHealth screeningClinical InterviewHealth problemsPregnancy care programsRoutine maternal careTertiary care hospitalMental health service provisionPrimary healthcare levelHigher EPDS scoresPostnatal Depression ScaleWeeks of periodPregnancy-associated conditionsMental health gapPatient-centered careHealth service provisionHealth surveillance systemsCare hospitalMiddle-income countriesPregnant womenCohort Profile: The Rajarata Pregnancy Cohort (RaPCo)
Agampodi S, Wickramasinghe N, Agampodi T. Cohort Profile: The Rajarata Pregnancy Cohort (RaPCo). Anuradhapura Medical Journal 2023, 17: 31. DOI: 10.4038/amj.v17i1.7757.Peer-Reviewed Original ResearchMaternal morbidityFirst trimesterPregnancy cohortPregnant womenFirst antenatal clinic visitEarly pregnancy miscarriageFatty liver gradePregnancy care programsFatty liver indexGestational age neonatesAntenatal clinic visitPregnancy outcome dataAnemic pregnant womenSignificant risk factorsComprehensive mental healthBaseline data collectionGestational diabetesAge neonatesClinic visitsCohort womenMetabolic syndromeMetabolic derangementsEarly pregnancyEntire cohortLiver indexSerum creatinine and estimated glomerular filtration rate (eGFR) in early pregnancy and changes during the pregnancy
Agampodi S, Agampodi T, Amarasinghe G, Warnasekara J, Hettiarachchi A, Jayasinghe I, Koralegedara I, Abeyrathna P, Srimantha S, de Silva F, Gunarathne S, Wickramasinghe N. Serum creatinine and estimated glomerular filtration rate (eGFR) in early pregnancy and changes during the pregnancy. PLOS Global Public Health 2023, 3: e0000443. PMID: 36962935, PMCID: PMC10021427, DOI: 10.1371/journal.pgph.0000443.Peer-Reviewed Original ResearchGlomerular filtration rateWeeks of gestationRenal functionPregnant womenNonpregnant womenSerum creatinineSecond trimesterEarly pregnancyFiltration rateClinical practiceCommunity-based prospective cohort studyProspective population-based studyPre-existing medical conditionsProspective cohort studyHealthy pregnant womenCommunity-based cohortPopulation-based studyDifferent age strataMean eGFRCohort studyNewborn outcomesNonpregnant groupPregnancy cohortFirst trimesterMean SCr
2022
The geo-spatial perspective of biological, social and environmental determinants of early pregnancy anaemia in rural Sri Lanka: Need for context-specific approaches on prevention
Amarasinghe G, Agampodi T, Mendis V, Agampodi S. The geo-spatial perspective of biological, social and environmental determinants of early pregnancy anaemia in rural Sri Lanka: Need for context-specific approaches on prevention. Geospatial Health 2022, 17 PMID: 36468596, DOI: 10.4081/gh.2022.1110.Peer-Reviewed Original ResearchConceptsPrevalence of anemiaEarly pregnancyPregnant womenRisk factorsFirst trimester pregnant womenHigher anemia prevalenceAntenatal care programsEnvironmental risk factorsHeterogeneous risk factorsMaternal anemiaPregnancy anemiaPregnancy cohortAnemia prevalenceDietary patternsHigh prevalenceAnemiaCare programRural Sri LankaPrevalenceSocioeconomic disparitiesPregnancyHealth DivisionEthnic distributionSignificant differencesAnuradhapura districtFatty Liver Index is a valid predictor of non-alcoholic fatty liver disease (NAFLD) in pregnancy
Koralegedara IS, Warnasekara JN, Rathnayake A, Dayaratne KG, Agampodi SB. Fatty Liver Index is a valid predictor of non-alcoholic fatty liver disease (NAFLD) in pregnancy. BMJ Open Gastroenterology 2022, 9: e000913. PMID: 35728866, PMCID: PMC9214354, DOI: 10.1136/bmjgast-2022-000913.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseFatty liver indexAdverse pregnancy outcomesFatty liver diseasePregnant womenPregnancy outcomesLiver diseaseFatty liverLiver indexFirst trimester pregnant womenGamma-glutamyl transferase levelsBody mass indexPeriod of gestationLogistic regression modelsBinary logistic regression modelIndependent predictorsMass indexPregnancy cohortEarly pregnancyMean ageTransferase levelsLiver enzymesUltrasound scanGeneral populationHealth setupDoes Being Diagnosed As Anemic in Early Pregnancy Have an Impact on the Household Expenditure for Food? Evidence From a Maternal Cohort in Rural Sri Lanka
Gunarathne S, Amarasinghe G, Agampodi T, Wickramasinghe N, Mendis V, Prasanna I, Agampodi S. Does Being Diagnosed As Anemic in Early Pregnancy Have an Impact on the Household Expenditure for Food? Evidence From a Maternal Cohort in Rural Sri Lanka. Current Developments In Nutrition 2022, 6: 654. PMCID: PMC9193294, DOI: 10.1093/cdn/nzac061.038.Peer-Reviewed Original ResearchNon-anaemic womenEarly pregnancyPregnant womenRural Sri LankaFirst trimester pregnant womenPublic health midwivesHousehold food expenditureThird of pregnanciesAnemic pregnant womenMann-Whitney U testDiagnosis of anemiaMonthly household incomeLifestyle modificationHemoglobin levelsPregnancy cohortThird trimesterMean ageModerate anemiaMaternal cohortAppropriate treatmentHousehold economic statusNutritional educationSelf-administrated questionnairePregnancyAnemiaDisease burden of cardiovascular conditions complicating pregnancy in Sri Lanka: a protocol
Hettiarachchi A, Lokunarangoda N, Agampodi T, Agampodi S. Disease burden of cardiovascular conditions complicating pregnancy in Sri Lanka: a protocol. F1000Research 2022, 10: 1028. DOI: 10.12688/f1000research.52539.3.Peer-Reviewed Original ResearchCardiovascular diseasePeriod of amenorrhoeaBurden of CVDEffects of CVDProspective cohort studyCardiovascular disease morbidityEvidence-based guidelinesRoutine clinical assessmentRisk prediction modelPostpartum morbidityPregnancy clinicWard admissionAntenatal careCohort studyMaternal deathsMiddle-income countriesCVD burdenDisease morbidityEarly pregnancyFirst trimesterPregnant womenMaternal mortalityAppropriate referralClinical examinationMedical causesComparison of global definitions of metabolic syndrome in early pregnancy among the Rajarata Pregnancy Cohort participants in Sri Lanka
Jayasinghe IU, Agampodi TC, Dissanayake AK, Srimantha SM, Agampodi SB. Comparison of global definitions of metabolic syndrome in early pregnancy among the Rajarata Pregnancy Cohort participants in Sri Lanka. Scientific Reports 2022, 12: 2009. PMID: 35132136, PMCID: PMC8821546, DOI: 10.1038/s41598-022-05919-z.Peer-Reviewed Original ResearchConceptsPeriod of gestationTotal cholesterolEarly pregnancyMetabolic syndromeMetabolic derangementsCohort participantsPrevalence estimatesOral glucose tolerance testHigher MetS prevalenceNCEP ATP IIIAHA/NHLBIGlucose tolerance testDifferent diagnostic criteriaSignificant differencesCross-sectional analysisAge 27.9MetS prevalencePregnancy outcomesSerum lipidsMetS definitionsProspective studyPregnant womenPlasma glucoseTolerance testMetabolic parametersEarly pregnancy hyperglycaemia as a significant predictor of large for gestational age neonates
Jayasinghe IU, Koralegedara IS, Agampodi SB. Early pregnancy hyperglycaemia as a significant predictor of large for gestational age neonates. Acta Diabetologica 2022, 59: 535-543. PMID: 34973071, PMCID: PMC8917036, DOI: 10.1007/s00592-021-01828-1.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusGestational age neonatesLGA neonatesAge neonatesGestational ageFirst trimesterPrevalence of GDMWorld Health Organization criteriaDelivery gestational ageNeonatal birth weightPregnancy Study GroupsBirth weight centileMedian gestational ageProspective cohort studyAttributable risk percentageHigh-risk populationUndiagnosed DMCohort studyCumulative incidenceDiabetes mellitusWeight centileEarly pregnancyPregnant womenMean ageOrganization criteria
2021
Disease burden and adverse pregnancy outcomes due to cardiovascular conditions complicating pregnancy in Sri Lanka: a protocol
Hettiarachchi A, Lokunarangoda N, Agampodi T, Agampodi S. Disease burden and adverse pregnancy outcomes due to cardiovascular conditions complicating pregnancy in Sri Lanka: a protocol. F1000Research 2021, 10: 1028. DOI: 10.12688/f1000research.52539.1.Peer-Reviewed Original ResearchCardiovascular diseasePeriod of amenorrhoeaBurden of CVDAdverse pregnancy outcomesEffects of CVDProspective cohort studyCardiovascular disease morbidityEvidence-based guidelinesRoutine clinical assessmentRisk prediction modelPostpartum morbidityPregnancy clinicWard admissionAntenatal careCohort studyPregnancy outcomesMaternal deathsMiddle-income countriesCVD burdenDisease morbidityEarly pregnancyFirst trimesterPregnant womenMaternal mortalityAppropriate referral