2009
Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G. Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells. Circulation 2009, 119: 1424-1432. PMID: 19255340, PMCID: PMC2898514, DOI: 10.1161/circulationaha.108.827618.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCD4-Positive T-LymphocytesCells, CulturedChemokine CXCL10Coronary Artery DiseaseCoronary VesselsFemaleGene Expression RegulationHumansInflammation MediatorsInterferon-gammaInterleukin-17Interleukin-6Interleukin-8InterleukinsMaleMiddle AgedMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptors, InterferonReceptors, Interleukin-17Signal TransductionT-Lymphocyte SubsetsTransforming Growth Factor beta1VasculitisConceptsVascular smooth muscle cellsSmooth muscle cellsIL-17IFN-gammaT cellsCoronary atherosclerosisMuscle cellsCoronary arteryIL-6Signature cytokinesIL-17 plasma levelsCultured vascular smooth muscle cellsIL-17 synthesisIL-17 responsesHuman coronary atherosclerosisIL-17 secretionSubset of patientsIL-17 producersT helper cellsIFN-gamma synthesisIFN-gamma producersYoung healthy individualsAtherosclerotic coronary arteriesHuman coronary arteriesTh17 cells
1995
IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro
Petzelbauer P, Watson C, Watson C, Pfau S, Pober J. IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro. Cytokine 1995, 7: 267-272. PMID: 7543779, DOI: 10.1006/cyto.1995.0031.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsIL-8Cultured human umbilical vein endothelial cellsDermal microvascular endothelial cellsEndothelial cellsHuman endothelial cellsRecombinant human IL-8IL-8 treatmentMicrovascular human endothelial cellsReceptor mRNA expressionEndothelial cell growth factorHuman IL-8Human dermal microvascular endothelial cellsMicrovascular endothelial cellsCytoplasmic calcium concentrationUmbilical vein endothelial cellsCell growth factorVein endothelial cellsAngiogenic factorsMRNA expressionDirect actionGrowth factorCalcium concentrationIndirect actionProliferative rate