2021
Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies
Adams TG, Cisler JM, Kelmendi B, George JR, Kichuk SA, Averill CL, Anticevic A, Abdallah CG, Pittenger C. Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies. Depression And Anxiety 2021, 39: 37-48. PMID: 34464485, PMCID: PMC8732293, DOI: 10.1002/da.23212.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationMedial prefrontal cortexDefault mode networkObsessive-compulsive disorderDirect current stimulationFunctional connectivityCurrent stimulationSham transcranial direct current stimulationResting-state functional magnetic resonanceSafety learningActive transcranial direct current stimulationEffects of tDCSMainstay of treatmentCommunity volunteersExposure-based psychotherapySuperior frontal gyrusFunctional magnetic resonanceBasal gangliaClinical trialsExposure-based therapyVivo exposureSalience networkSubjective emotional distressAnterior insulaPrefrontal cortex
2016
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding
Pittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. Journal Of Affective Disorders 2016, 196: 87-96. PMID: 26919057, PMCID: PMC4808438, DOI: 10.1016/j.jad.2016.02.021.Peer-Reviewed Original ResearchConceptsPrepulse inhibitionObsessive-compulsive disorderReceptor availabilitySensorimotor gatingOCD patientsImpaired sensorimotor gatingOCD-like behaviorNon-depressed OCD patientsPositron emission tomographyBasal gangliaSerotonergic regulationHealthy controlsSerotonin systemPositive correlationWidespread positive correlationsDiagnostic groupsCortical regionsEmission tomographyOrbitofrontal cortexPatientsReceptor bindingOCD diagnosisSignificant correlationSignificant main effectImportant alterations