Featured Publications
The Addiction Recovery Clinic
Holt SR, Segar N, Cavallo DA, Tetrault JM. The Addiction Recovery Clinic. Academic Medicine 2017, 92: 680-683. PMID: 28441678, DOI: 10.1097/acm.0000000000001480.Peer-Reviewed Original ResearchConceptsPatient satisfaction surveyInternal medicine residentsRecovery clinicSubstance useMedicine residentsUse disordersAddiction medicine specialistsOpioid use disorderOutpatient clinical servicesPrimary care practicesUnhealthy substance useSubstance use disordersAddiction treatment facilitiesSatisfaction surveyDirect referralNew patientsMedicine specialistsPatientsCare practicesPatient encountersConsecutive weeksBehavioral treatmentAddiction medicineClinical servicesVisit numberEffective Strategies for Planning and Facilitating Morning Report.
Elisseou S, Holt SR. Effective Strategies for Planning and Facilitating Morning Report. Journal Of Graduate Medical Education 2022, 14: 260-264. PMID: 35754651, PMCID: PMC9200236, DOI: 10.4300/jgme-d-21-01084.1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCreating a Satisfying Continuity Clinic Experience for Primary Care Trainees
Holt S, Tobin D, Whitman L, Ellman M, Moriarty J, Doolittle B. Creating a Satisfying Continuity Clinic Experience for Primary Care Trainees. The American Journal Of Medicine 2020, 134: 547-553. PMID: 33385340, DOI: 10.1016/j.amjmed.2020.12.005.Peer-Reviewed Original ResearchFactors Affecting Resident Satisfaction in Continuity Clinic—a Systematic Review
Stepczynski J, Holt SR, Ellman MS, Tobin D, Doolittle BR. Factors Affecting Resident Satisfaction in Continuity Clinic—a Systematic Review. Journal Of General Internal Medicine 2018, 33: 1386-1393. PMID: 29736753, PMCID: PMC6082200, DOI: 10.1007/s11606-018-4469-8.Peer-Reviewed Original ResearchConceptsContinuity clinicAmbulatory trainingMethodsA systematic literature reviewCochrane Central RegisterControlled Clinical TrialsResultsThree hundred fiftyContinuity of careEnglish-language articlesQuality of lifeCentral RegisterClinical trialsHundred fiftyAmbulatory careExclusion criteriaPurposeIn recent yearsSystematic reviewLanguage articlesFinal reviewResident satisfactionSearch termsClinicRelevant databasesSystematic literature reviewCareTrainee satisfaction
2024
Supervised Disulfiram Should Be Considered First-line Treatment for Alcohol Use Disorder
Holt S. Supervised Disulfiram Should Be Considered First-line Treatment for Alcohol Use Disorder. Journal Of Addiction Medicine 2024, 18: 614-616. PMID: 39150091, DOI: 10.1097/adm.0000000000001345.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSupervised disulfiramUse disorderAlcohol use disorder treatmentPrevalence of alcohol use disordersFDA-approved medicationsRandomized controlled trialsFirst-line interventionBehavioral interventionsDouble-blind randomized controlled trialApproved medicationsDisulfiramOpen-label randomized controlled trialSecond-line optionFirst-line treatmentNational treatment guidelinesDisordersTherapeutic resourcesEfficacy dataMedicationTreatment guidelinesAddictionControlled trialsInterventionPatient preferences
2023
Chief resident behaviors that lead to effective morning reports, a multisite qualitative study
Yang Y, Schulze A, Bekui A, Elisseou S, Sun S, Hay S, Moriarty J, Holt S. Chief resident behaviors that lead to effective morning reports, a multisite qualitative study. BMC Medical Education 2023, 23: 789. PMID: 37875921, PMCID: PMC10598973, DOI: 10.1186/s12909-023-04762-8.Peer-Reviewed Original ResearchConceptsMorning reportPedagogical approachFaculty participationInnovative teaching strategiesSafe learning environmentChief residentsInvolvement of facultyEffective presentation skillsQualitative studyTeaching strategiesLearning environmentFaculty developmentPresentation skillsTeaching responsibilitiesDelivery skillsContent preparationClinical reasoningInternal medicine programsTime managementPreparation domainsMultisite qualitative studyInternal medicine trainingMedicine programsMedicine trainingThematic sufficiency
2020
Responding to Unsafe Opioid Use: Abandon the Drug, Not the Patient
Tobin DG, Holt SR, Doolittle BR. Responding to Unsafe Opioid Use: Abandon the Drug, Not the Patient. Journal Of General Internal Medicine 2020, 36: 790-791. PMID: 33037590, PMCID: PMC7947064, DOI: 10.1007/s11606-020-06281-4.Commentaries, Editorials and LettersComputerized Cognitive Behavioral Therapy for Substance Use Disorders in a Specialized Primary Care Practice: A Randomized Feasibility Trial to Address the RT Component of SBIRT.
Tetrault JM, Holt SR, Cavallo DA, O'Connor PG, Gordon MA, Corvino JK, Nich C, Carroll KM. Computerized Cognitive Behavioral Therapy for Substance Use Disorders in a Specialized Primary Care Practice: A Randomized Feasibility Trial to Address the RT Component of SBIRT. Journal Of Addiction Medicine 2020, 14: e303-e309. PMID: 32371660, DOI: 10.1097/adm.0000000000000663.Peer-Reviewed Original ResearchConceptsSubstance use disordersComputerized cognitive behavioral therapySubstance useCognitive behavioral therapySelf-reported substance useUse disordersTechnology-based treatmentsPrimary care settingSubstance use outcomesIntegrated addictions treatmentTechnology-based interventionsBehavioral therapyPrimary care practicesOverall positive outcomeSUD interventionsBrief interventionUnhealthy alcohol useDays abstinentPositive outcomesUse outcomesCare settingsAlcohol useStandard careAddiction treatmentTreatment settings
2019
A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders
Ahmed OM, Mao JA, Holt SR, Hawk K, D'Onofrio G, Martel S, Melnick ER. A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders. Journal Of Substance Use And Addiction Treatment 2019, 102: 47-52. PMID: 31202288, PMCID: PMC6578846, DOI: 10.1016/j.jsat.2019.05.006.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersCommunity providersCommunity sitesEmergency department-initiated buprenorphineTreatment referral programNeeds assessmentStakeholder meetingsKey stakeholder meetingsED referralsED cliniciansEmergency departmentWarm handoffsMOUDReferral systemReferral processSite referralTrials NetworkPatient identifiersReferral programReferralMedicationsPatientsHIPAA-compliant mannerDisordersPhysicians Should Play a Role in Ensuring Safe Firearm Ownership
Holt SR, Rosenbaum J, Ellman M, Doolittle B, Tobin DG. Physicians Should Play a Role in Ensuring Safe Firearm Ownership. Journal Of General Internal Medicine 2019, 34: 1637-1640. PMID: 31062224, PMCID: PMC6667526, DOI: 10.1007/s11606-019-05034-2.Commentaries, Editorials and Letters
2018
Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial
Edelman EJ, Moore BA, Holt SR, Hansen N, Kyriakides TC, Virata M, Brown ST, Justice AC, Bryant KJ, Fiellin DA, Fiellin LE. Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial. AIDS And Behavior 2018, 23: 211-221. PMID: 30073637, PMCID: PMC6476298, DOI: 10.1007/s10461-018-2241-z.Peer-Reviewed Original ResearchConceptsHIV-positive patientsHeavy drinking daysVACS Index scoreXR-NTXART adherenceDrinking daysIndex scoreUndetectable HIV viral loadCD4 cell countExtended-release naltrexoneDouble-blind placeboHIV viral loadRandomized-controlled trialDrinking outcomesHIV biomarkersSecondary outcomesHIV outcomesPrimary outcomeViral loadAntiretroviral adherenceClinical trialsCell countAlcohol treatmentHIVPatientsPharmacotherapy for Alcohol Use Disorder
Holt SR, Tobin DG. Pharmacotherapy for Alcohol Use Disorder. Medical Clinics Of North America 2018, 102: 653-666. PMID: 29933821, DOI: 10.1016/j.mcna.2018.02.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol use disorderUse disordersNondrug therapiesUndertreated diseaseTreatment optionsPharmacotherapeutic agentsDrug interactionsTreatment goalsUS FoodDrug AdministrationSpecific patientDrug availabilityDisordersPatientsCounseling strategiesComorbiditiesMedicationsPharmacotherapyOptionsTherapyDiseaseAdministrationCareAddressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder
Holt SR, Donroe JH, Cavallo DA, Tetrault JM. Addressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder. Drug And Alcohol Dependence 2018, 186: 171-174. PMID: 29579725, DOI: 10.1016/j.drugalcdep.2017.12.040.Peer-Reviewed Original ResearchConceptsOngoing illicit drug usePatient-provider relationshipOpioid use disorderIllicit drug useUse disordersUrine adulterationTreatment planDrug useQuantitative urine testingMethadone treatment programsSubstance use disordersNorbuprenorphine levelsUrine buprenorphineUrine testingPatientsTreatment programNonjudgmental approachUrine samplesTherapeutic allianceDiscordant levelsBuprenorphineDisordersUrineNorbuprenorphineLevels
2017
Objective Structured Clinical Examination–Based Teaching of the Musculoskeletal Examination
Siddharthan T, Soares S, Wang HH, Holt SR. Objective Structured Clinical Examination–Based Teaching of the Musculoskeletal Examination. Southern Medical Journal 2017, 110: 761-764. PMID: 29197309, DOI: 10.14423/smj.0000000000000739.Peer-Reviewed Original ResearchConceptsUnexposed residentsClinical skill testClinical examinationStandardized patientsObjective Structured Clinical ExaminationStructured Clinical ExaminationCommon presenting illnessPrimary care settingPrimary care residency programsClinical skillsInternal medicine residentsPresenting illnessMusculoskeletal complaintsTherapeutic planMedical studentsDifferential diagnosisCare settingsMusculoskeletal examinationVolunteer medical studentsImpact of exposureMedical education needsMedicine residentsConvenience samplePhysical examination skillsSuch complaintsInterpreting quantitative urine buprenorphine and norbuprenorphine levels in office-based clinical practice
Donroe JH, Holt SR, O’Connor P, Sukumar N, Tetrault JM. Interpreting quantitative urine buprenorphine and norbuprenorphine levels in office-based clinical practice. Drug And Alcohol Dependence 2017, 180: 46-51. PMID: 28866369, DOI: 10.1016/j.drugalcdep.2017.07.040.Peer-Reviewed Original ResearchConceptsOpioid use disorderUrine buprenorphineNorbuprenorphine levelsUrine adulterationAddiction treatment clinicsTreatment clinicsBuprenorphine medicationSublingual buprenorphineBuprenorphine treatmentTreatment cohortsRetrospective studyUrine specimenBuprenorphineUse disordersPatientsClinical practiceUrine samplesUrineClinicTreatmentMedicationsLevelsNorBUPCohortSuspicionResident and Faculty Perceptions of Chart-Stimulated Recall
Holt SR, Sofair AN. Resident and Faculty Perceptions of Chart-Stimulated Recall. Southern Medical Journal 2017, 110: 142-146. PMID: 28158886, DOI: 10.14423/smj.0000000000000600.Peer-Reviewed Original Research
2016
Caring for patients with opioid use disorder in the hospitalCaring for patients with opioid use disorder in the hospital
Donroe JH, Holt SR, Tetrault JM. Caring for patients with opioid use disorder in the hospitalCaring for patients with opioid use disorder in the hospital. Canadian Medical Association Journal 2016, 188: cmaj.160290. PMID: 27647616, PMCID: PMC5135493, DOI: 10.1503/cmaj.160290.Peer-Reviewed Original ResearchUnhealthy Alcohol Use
Holt S, Tetrault J. Unhealthy Alcohol Use. Clinics In Liver Disease 2016, 20: 429-444. PMID: 27373607, DOI: 10.1016/j.cld.2016.02.003.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol useSymptom-triggered approachAlcohol use disorderAlcohol withdrawalAppropriate treatmentRoutine screeningPatient motivationUse disordersBrief interventionHazardous drinkingBehavioral therapyHeavy drinkingPatientsRobust dataBehavioral changesDrinkingTwelve-step programsMedicationsTherapyBenzodiazepinesAbstinence
2013
Instruments to assess patient‐reported safety, efficacy, or misuse of current opioid therapy for chronic pain: A systematic review
Becker WC, Fraenkel L, Edelman J, Holt SR, Glover J, Kerns RD, Fiellin DA. Instruments to assess patient‐reported safety, efficacy, or misuse of current opioid therapy for chronic pain: A systematic review. Pain 2013, 154: 905-916. PMID: 23601625, PMCID: PMC3683236, DOI: 10.1016/j.pain.2013.02.031.Peer-Reviewed Original ResearchConceptsPatient-reported safetyOpioid therapyChronic painInclusion criteriaSystematic reviewOngoing opioid therapyPsychometric testsLack of testingEligible studiesClinical practiceInitial searchStatistical significanceDiagnostic accuracy testingPainEfficacyTherapyEfficacy itemsContent expertsSafetyLimited assessmentReviewLiterature reviewGeneralizability limitationsFurther researchIndividual items
2012
Physician Detection of Unhealthy Substance Use on Inpatient Teaching and Hospitalist Medical Services
Holt SR, Ramos J, Harma M, Cabrera F, Louis-Ashby C, Dinh A, Fiellin DA, Tetrault JM. Physician Detection of Unhealthy Substance Use on Inpatient Teaching and Hospitalist Medical Services. The American Journal Of Drug And Alcohol Abuse 2012, 39: 121-129. PMID: 22992028, DOI: 10.3109/00952990.2012.715703.Peer-Reviewed Original ResearchConceptsUnhealthy substance useAlcohol Use Disorders Identification Test-ConsumptionDrug Abuse Screening TestHospitalist serviceSubstance useScreening testSubstance Involvement Screening TestPhysicians' detection ratesUnhealthy drug useMedical record reviewTeaching serviceCommunity teaching hospitalMedical servicesCross-sectional studyICD-9 codingRate of detectionAbuse Screening TestEligible patientsMedicine admissionsCurrent smokersRecord reviewDetection ratePhysician detectionTeaching hospitalPhysician documentation