Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
Wisnovsky S, Möckl L, Malaker SA, Pedram K, Hess GT, Riley NM, Gray MA, Smith BAH, Bassik MC, Moerner WE, Bertozzi CR. Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2015024118. PMID: 33495350, PMCID: PMC7865165, DOI: 10.1073/pnas.2015024118.Peer-Reviewed Original ResearchAmino Acid MotifsAntigens, Differentiation, MyelomonocyticCell Line, TumorCell MembraneClustered Regularly Interspaced Short Palindromic RepeatsGenome, HumanGlycopeptidesHumansImmunological SynapsesKiller Cells, NaturalLectinsLeukosialinLigandsPolysaccharidesProtein Binding