2020
Targeted glycan degradation potentiates the anticancer immune response in vivo
Gray MA, Stanczak MA, Mantuano NR, Xiao H, Pijnenborg JFA, Malaker SA, Miller CL, Weidenbacher PA, Tanzo JT, Ahn G, Woods EC, Läubli H, Bertozzi CR. Targeted glycan degradation potentiates the anticancer immune response in vivo. Nature Chemical Biology 2020, 16: 1376-1384. PMID: 32807964, PMCID: PMC7727925, DOI: 10.1038/s41589-020-0622-x.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsAntibodies, MonoclonalB7-H1 AntigenCell Line, TumorHumansHydrolysisImmunoconjugatesImmunotherapyKiller Cells, NaturalMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutModels, MolecularMolecular Targeted TherapyNeuraminidasePolysaccharidesProgrammed Cell Death 1 ReceptorProtein BindingProtein Interaction Domains and MotifsProtein Structure, SecondaryReceptor, ErbB-2Sialic Acid Binding Immunoglobulin-like LectinsSurvival AnalysisT-LymphocytesConceptsImmune checkpoint inhibitor therapyTumor-infiltrating myeloid cellsCheckpoint inhibitor therapyImmune cell infiltrationPowerful treatment optionAnticancer immune responseSurvival of miceSyngeneic breast cancer modelImmune cell activationBreast cancer modelBreast cancer cellsCheckpoint therapyMost patientsInhibitor therapyPD-1Checkpoint receptorsImmune suppressionTreatment optionsCell infiltrationImmune responseMyeloid cellsCancer modelCell activationCertain cancersCancer types
2017
Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles
Pavlos R, McKinnon EJ, Ostrov DA, Peters B, Buus S, Koelle D, Chopra A, Schutte R, Rive C, Redwood A, Restrepo S, Bracey A, Kaever T, Myers P, Speers E, Malaker SA, Shabanowitz J, Jing Y, Gaudieri S, Hunt DF, Carrington M, Haas DW, Mallal S, Phillips EJ. Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles. Scientific Reports 2017, 7: 8653. PMID: 28819312, PMCID: PMC5561238, DOI: 10.1038/s41598-017-08876-0.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsHLA moleculesTreatment-limiting hypersensitivity reactionClass IDrug hypersensitivity syndromeHuman leukocyte antigen (HLA) systemHLA class IHLA-C allelesClass II allelesLeukocyte antigen systemHLA-B allelesNevirapine hypersensitivityHypersensitivity syndromeHLA associationsIndependent associationHLA-DRB1T cellsImmune responseNovel risk allelesPathogenic mechanismsDrug specific interactionsMultiple class IAntigen systemPrimary predispositionRisk allelesIdentification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia
Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M. Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia. Cancer Immunology Research 2017, 5: 376-384. PMID: 28314751, PMCID: PMC5508727, DOI: 10.1158/2326-6066.cir-16-0280.Peer-Reviewed Original Research
2013
MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
Cobbold M, De La Peña H, Norris A, Polefrone JM, Qian J, English AM, Cummings KL, Penny S, Turner JE, Cottine J, Abelin JG, Malaker SA, Zarling AL, Huang HW, Goodyear O, Freeman SD, Shabanowitz J, Pratt G, Craddock C, Williams ME, Hunt DF, Engelhard VH. MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia. Science Translational Medicine 2013, 5: 203ra125. PMID: 24048523, PMCID: PMC4071620, DOI: 10.1126/scitranslmed.3006061.Peer-Reviewed Original ResearchConceptsT cellsImmune surveillanceAllogeneic stem cell transplantationMajor histocompatibility complex class IStem cell transplantationT cell responsesHistocompatibility complex class IAdoptive transfer immunotherapyCancer immune surveillanceHuman leukocyte antigenComplex class ICell linesPrimary leukemia cellsT cell linesClinical outcomesCell transplantationLeukocyte antigenLeukemia patientsMemory compartmentHematological tumorsHealthy individualsLeukemia cell linesCell responsesMalignant transformationNormal tissues