2023
Adjusting for population stratification in polygenic risk score analyses: a guide for model specifications in the UK Biobank
Lin B, Pries L, van Os J, Luykx J, Rutten B, Guloksuz S. Adjusting for population stratification in polygenic risk score analyses: a guide for model specifications in the UK Biobank. Journal Of Human Genetics 2023, 68: 653-656. PMID: 37188914, DOI: 10.1038/s10038-023-01161-1.Peer-Reviewed Original ResearchMeSH KeywordsBiological Specimen BanksDepressive Disorder, MajorGenome-Wide Association StudyHumansMultifactorial InheritancePhenotypeRisk FactorsUnited Kingdom
2022
Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants
Lin B, Pries L, Sarac H, van Os J, Rutten B, Luykx J, Guloksuz S. Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants. JAMA Psychiatry 2022, 79: 857-868. PMID: 35857297, PMCID: PMC9301596, DOI: 10.1001/jamapsychiatry.2022.1655.Peer-Reviewed Original ResearchPolygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Fusar-Poli L, Rutten B, van Os J, Aguglia E, Guloksuz S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? International Review Of Psychiatry 2022, 34: 663-675. PMID: 36786114, DOI: 10.1080/09540261.2022.2101352.Peer-Reviewed Original ResearchMeSH KeywordsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMental DisordersMultifactorial InheritancePsychiatryRisk FactorsConceptsPolygenic risk scoresTreatment responseRisk scoreMental disordersDetailed clinical characterizationPresent narrative reviewPotential clinical utilityMajor mental disordersIndividual genetic predispositionRisk stratificationPrognostic evaluationClinical characterizationWide association study datasetsClinical utilityGeneral populationGenetic predispositionNarrative reviewSingle nucleotide polymorphismsMapping genomic loci implicates genes and synaptic biology in schizophrenia
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022, 604: 502-508. PMID: 35396580, PMCID: PMC9392466, DOI: 10.1038/s41586-022-04434-5.Peer-Reviewed Original ResearchMeSH KeywordsAllelesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansPolymorphism, Single NucleotideSchizophreniaConceptsGenomic lociTwo-stage genome-wide association studyVariant associationsDistinct genomic lociGenome-wide association studiesTranscription factor Sp4Functional genomics dataCommon variant associationsRare variant associationsCommon risk allelesSynaptic biologyGenomic dataBiological processesAssociation studiesGenesCell typesNeurodevelopmental disordersRegion variationLociFundamental processesNeuronal functionSuch variantsRisk allelesMechanistic studiesVariants
2021
Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status
Pasman J, Demange P, Guloksuz S, Willemsen A, Abdellaoui A, ten Have M, Hottenga J, Boomsma D, de Geus E, Bartels M, de Graaf R, Verweij K, Smit D, Nivard M, Vink J. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics 2021, 52: 92-107. PMID: 34855049, PMCID: PMC8860781, DOI: 10.1007/s10519-021-10094-4.Peer-Reviewed Original ResearchMeSH KeywordsGenome-Wide Association StudyHumansMultifactorial InheritanceNetherlandsSmokingSocial ClassConceptsLifetime smokingSocioeconomic statusNetherlands Mental Health SurveyMental healthIncidence Study-2Mental Health SurveyNeighborhood socioeconomic statusGenome-wide association studiesGenetic liabilityHealth SurveySmokingGene-environment interactionsEducational attainmentEA effectNetherlands Twin RegisterSmoking traitsGenetic riskPolygenic scoresEtiology of smokingPredictive profilesTwin RegisterSES characteristicsUK BiobankReliable predictorHealth
2020
A new genetic locus for antipsychotic-induced weight gain: A genome-wide study of first-episode psychosis patients using amisulpride (from the OPTiMiSE cohort)
Hark S, Jamain S, Schijven D, Lin B, Bakker M, Boland-Auge A, Deleuze J, Troudet R, Malhotra A, Gülöksüz S, Vinkers C, Ebdrup B, Kahn R, Leboyer M, Luykx J. A new genetic locus for antipsychotic-induced weight gain: A genome-wide study of first-episode psychosis patients using amisulpride (from the OPTiMiSE cohort). Journal Of Psychopharmacology 2020, 34: 524-531. PMID: 32126890, PMCID: PMC7222287, DOI: 10.1177/0269881120907972.Peer-Reviewed Original Research
2017
DNA Methylation in Schizophrenia
Pries L, Gülöksüz S, Kenis G. DNA Methylation in Schizophrenia. Advances In Experimental Medicine And Biology 2017, 978: 211-236. PMID: 28523549, DOI: 10.1007/978-3-319-53889-1_12.Peer-Reviewed Original ResearchConceptsAberrant DNA modificationsGenome-wide approachesDNA methylation changesCandidate gene studiesHigh heritability estimatesGenetic susceptibility lociHeritable psychiatric conditionEpigenetic mechanismsDNA methylationEpigenetic processesMethylation changesDNA modificationsComplex phenotypesGene studiesSusceptibility lociHeritability estimatesRelevant environmental risk factors