2020
Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPain
2015
Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology
Guloksuz S, van Nierop M, Lieb R, van Winkel R, Wittchen H, van Os J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 2015, 45: 2389-2401. PMID: 25804288, DOI: 10.1017/s0033291715000380.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child Adverse EventsDiagnostic and Statistical Manual of Mental DisordersEnvironmental ExposureFemaleGermanyHelp-Seeking BehaviorHumansMaleModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPsychopathologyPsychotic DisordersRisk FactorsSeverity of Illness IndexSubstance-Related DisordersUrban PopulationYoung AdultConceptsNon-psychotic disordersNon-psychotic psychopathologyRisk factorsMood disordersPsychotic experiencesHelp-seeking behaviorDSM-IV mood disordersEnvironmental exposuresSevere clinical stateDose-response fashionEnvironmental risk factorsPresence of psychosisIndex of severitySubthreshold psychotic experiencesIllness severityClinical stateGeneral psychopathologyCannabis useDisordersSeverityCompulsive disorderPsychotic psychopathologyPsychosisPsychopathologyTrauma