Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 2020, 52: 1910-1922. PMID: 33070791, DOI: 10.1017/s0033291720003748.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersChildhood adversityRisk factorsNEMESIS-2Affective dysregulationNon-genetic risk factorsSignificant depressive symptomsSample of patientsRepresentative general population sampleGenetic risk factorsGeneral population sampleSchizophrenia polygenic riskPsychosis outcomesSpectrum disorderDepressive symptomsPRS-SZPolygenic riskDysregulationPatientsPopulation samplePsychosisAffective pathwayDisordersHallucinatory experiencesDelusional ideationAssociation of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort
Guloksuz S, Pries L, Ten Have M, de Graaf R, van Dorsselaer S, Klingenberg B, Bak M, Lin B, van Eijk K, Delespaul P, van Amelsvoort T, Luykx J, Rutten B, van Os J. Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort. World Psychiatry 2020, 19: 199-205. PMID: 32394548, PMCID: PMC7215054, DOI: 10.1002/wps.20755.Peer-Reviewed Original ResearchPsychosis high-risk statePopulation attributable fractionHigh-risk stateNon-psychotic mental disordersPsychosis risk statesDrug use disordersClinical high riskPsychosis incidenceProspective studyClinical psychosisIncidence rateMood disordersUse disordersMental disordersPopulation-based prospective studyCox proportional hazards modelProportional hazards modelHigher relative riskDSM-IV diagnosisPopulation-based improvementsRisk stateComprehensive prevention strategyAttributable fractionRelative riskPsychosis outcomes