2024
T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK
Lin B, Pries L, Magnasco A, Gülöksüz S. T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK. European Neuropsychopharmacology 2024, 87: 195-196. DOI: 10.1016/j.euroneuro.2024.08.388.Peer-Reviewed Original ResearchExposome-wide association studyPolygenic risk scoresPRS-SCZGene-environment interactionsGene-environment interaction studiesPsychotic experiencesAssociation studiesPhysical health outcomesLogistic regression modelsNon-psychotic disordersHealth outcomesUK BiobankMental distressNominal significanceRisk scoreMedical conditionsSleep problemsSelf-harm behaviorsRegression modelsAdditive interactionGxE interactionsAgnostic analysisGxEGenetic underpinningsExposure to PE401. Gene-Environment Interaction Study on the Correlates for Psychotic Experiences in the UK Biobank
Lin B, Pries L, Magnasco A, Guloksuz S. 401. Gene-Environment Interaction Study on the Correlates for Psychotic Experiences in the UK Biobank. Biological Psychiatry 2024, 95: s264. DOI: 10.1016/j.biopsych.2024.02.900.Peer-Reviewed Original Research
2020
Predictive Performance of Exposome Score for Schizophrenia in the General Population
Pries L, Erzin G, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Guloksuz S. Predictive Performance of Exposome Score for Schizophrenia in the General Population. Schizophrenia Bulletin 2020, 47: 277-283. PMID: 33215211, PMCID: PMC7965069, DOI: 10.1093/schbul/sbaa170.Peer-Reviewed Original ResearchConceptsES-SCZOptimal cut pointGeneral populationPopulation cohortGeneral population cohortCut pointsExposome scoreSchizophrenia spectrum disordersMeta-analytical estimatesClinical outcomesRisk strataRisk stratificationMulticausal etiologyMedical outcomesPsychiatric diagnosisBipolar disorderSchizophrenia diagnosisExposure scoreSuicide planSum scoreGene-environment interaction studiesSchizophreniaRisk predictionCharacteristic curveScores
2019
Organization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study
Xenaki L, Kollias C, Stefanatou P, Ralli I, Soldatos R, Dimitrakopoulos S, Hatzimanolis A, Triantafyllou T, Kosteletos I, Vlachos I, Selakovic M, Foteli S, Mantonakis L, Ermiliou V, Voulgaraki M, Psarra E, Gülöksüz S, van Os J, Stefanis N. Organization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study. Early Intervention In Psychiatry 2019, 14: 343-355. PMID: 31402581, DOI: 10.1111/eip.12865.Peer-Reviewed Original ResearchConceptsRisk factorsMild functional improvementLongitudinal cohort studySymptom severity criteriaPoor cognitive performanceOutcome of psychosisPreliminary findingsPatients 16Cohort studyAntipsychotic treatmentClinical pictureFEP patientsClinical managementFunctional improvementFamily historyEmergency unitBaseline presentationSeverity criteriaPsychiatric hospitalPsychotic disordersClinical InterviewDrug usePotential associationGene-environment interaction studiesBiochemical parameters