2020
Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
Erzin G, Özkaya G, Topçuoğlu C, Yüksel R, Erel Ö, Yurt E, Göka E, Gülöksüz S. Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression. Clinical Psychopharmacology And Neuroscience 2020, 18: 395-401. PMID: 32702218, PMCID: PMC7383011, DOI: 10.9758/cpn.2020.18.3.395.Peer-Reviewed Original ResearchDisulfide/total thiol ratiosTotal thiol ratiosThiol-disulfide homeostasisBipolar depressionHealthy controlsUnipolar depressionNative thiol ratioBipolar disorderDisulfide levelsThiol ratioDepressive disorderNative thiolAnkara Numune TrainingThiol/disulfide homeostasisDisulfide/native thiol ratioOxidative stress markersUnipolar depressive disorderDSM-5 criteriaLevels of disulfideUD groupOutpatient clinicClinical entityDepressive episodeResearch HospitalTherapeutic differences
2015
The impact of electroconvulsive therapy on the tryptophan–kynurenine metabolic pathway
Guloksuz S, Arts B, Walter S, Drukker M, Rodriguez L, Myint A, Schwarz M, Ponds R, van Os J, Kenis G, Rutten B. The impact of electroconvulsive therapy on the tryptophan–kynurenine metabolic pathway. Brain Behavior And Immunity 2015, 48: 48-52. PMID: 25765557, DOI: 10.1016/j.bbi.2015.02.029.Peer-Reviewed Original ResearchConceptsTrp-Kyn pathwayHamilton Depression Rating Scale-17 itemsElectroconvulsive therapyBeck Depression InventoryMechanism of actionKynurenic acidTrp-KynKyn/Trp ratioKYNA/KYN ratioTryptophan-kynurenine metabolic pathwayLast ECT sessionBilateral electroconvulsive therapyKyn/TrpTreatment of depressionMultilevel linear regression analysesKYN metabolitesECT sessionsAntidepressant effectsECT responseBipolar depressionECT treatmentTrp ratioNeuroprotective propertiesKynurenine pathwayNeurotoxic processes