2024
T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK
Lin B, Pries L, Magnasco A, Gülöksüz S. T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK. European Neuropsychopharmacology 2024, 87: 195-196. DOI: 10.1016/j.euroneuro.2024.08.388.Peer-Reviewed Original ResearchExposome-wide association studyPolygenic risk scoresPRS-SCZGene-environment interactionsGene-environment interaction studiesPsychotic experiencesAssociation studiesPhysical health outcomesLogistic regression modelsNon-psychotic disordersHealth outcomesUK BiobankMental distressNominal significanceRisk scoreMedical conditionsSleep problemsSelf-harm behaviorsRegression modelsAdditive interactionGxE interactionsAgnostic analysisGxEGenetic underpinningsExposure to PE
2019
Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
Guloksuz S, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş‐Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García‐Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez‐López E, Arrojo M, Carracedo A, López G, González‐Peñas J, Parellada M, Maric N, Atbaşog˘lu C, Ucok A, Alptekin K, Saka M, investigators G, Arango C, O'Donovan M, Rutten B, van Os J. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry 2019, 18: 173-182. PMID: 31059627, PMCID: PMC6502485, DOI: 10.1002/wps.20629.Peer-Reviewed Original ResearchSchizophrenia spectrum disordersEnvironmental exposuresGene-environment interactionsEtiopathogenesis of schizophreniaAdditive interactionEarly life adversityEarly TwinSeason of birthPolygenic risk scoresSpectrum disorderMultiple common genetic variantsRisk scoreRegular cannabisLifetime historyJoint associationsPRS-SCZCommon genetic variantsHearing impairmentSchizophreniaUnrelated controlsEUGEI studyDisordersFamily studiesGenetic liabilityRisk state