2024
Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2023
Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults
Li G, Chen Y, Chaudhary S, Li C, Hao D, Yang L, Li C. Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults. NeuroImage 2023, 279: 120340. PMID: 37611815, DOI: 10.1016/j.neuroimage.2023.120340.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexRight insulaSymptom severityMediation analysisSleep dysfunctionWhole-brain regressionHuman Connectome Project datasetSubjective mood stateYoung adultsState functional connectivityDepression symptom severityNegative emotionsCognitive performanceEmotional deficitsEmotional statesPotential sex differencesAffective functionsDrinking severityMood statesMotivated behaviorFunctional connectivityPoor sleep qualityRSFCSleep Quality IndexSleep qualityResting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals
Dong X, Zhornitsky S, Wang W, Le T, Chen Y, Chaudhary S, Li C, Zhang S. Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. The International Journal Of Neuropsychopharmacology 2023, 26: 627-638. PMID: 37579016, PMCID: PMC10519818, DOI: 10.1093/ijnp/pyac019.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityInferior frontal cortexCocaine-dependent individualsHealthy controlsVentral striatumCocaine useDorsal striatumAbstinent cocaine-dependent individualsCocaine misuseFunctional connectivityYears of drinkingLeft orbitofrontal cortexBIS-11 scoresRecent cocaine useLeft inferior frontal cortexDopaminergic deficitCortex connectivityFrontal cortexSeparate cohortHuman studiesSeverity of useAnimal studiesSecond cohortOrbitofrontal cortexBarratt Impulsivity ScaleAge-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuitsThe effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscoresShared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task
Chen Y, Chaudhary S, Li C. Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task. NeuroImage 2022, 264: 119764. PMID: 36427755, PMCID: PMC9837714, DOI: 10.1016/j.neuroimage.2022.119764.Peer-Reviewed Original ResearchConceptsSupplementary motor areaMonetary incentive delay taskMedial orbitofrontal cortexBilateral anterior insulaLoss outcomesAnterior insulaLoss anticipationIncentive delay taskBilateral striatumPrecentral gyrusCingulate cortexBilateral medial orbitofrontal cortexDorsal anterior cingulate cortexRight occipital cortexDelay taskAnterior cingulate cortexPosterior cingulate cortexNeural correlatesActivation likelihood estimationRight thalamusMotor areaOccipital cortexRegional activityDistinct neural activityStriatumOvernight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers
Chen Y, Dhingra I, Chaudhary S, Fucito L, Li CR. Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers. Nicotine & Tobacco Research 2022, 24: 1889-1897. PMID: 35796689, PMCID: PMC9653081, DOI: 10.1093/ntr/ntac168.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityGray matter volumeWithdrawal symptom severityOvernight abstinenceFunctional connectivityRight SIISymptom severityCigarette smokersSomatosensory cortexMatter volumeRight secondary somatosensory cortexSmaller gray matter volumeSubcortical gray matter volumesSecond somatosensory cortexSecondary somatosensory cortexCortical functional connectivityMotor impulsivityVoxel-wise morphometryRegional gray matter volumeLeft ventral hippocampusGMV alterationsCigarette smokingSatiety stateAbstinence symptomsHigher-order sensory corticesLoss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers
Li G, Chen Y, Chaudhary S, Tang X, Li CR. Loss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 1007-1016. PMID: 35709958, PMCID: PMC10249655, DOI: 10.1016/j.bpsc.2022.06.001.Peer-Reviewed Original ResearchEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemoryThe effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity
Chaudhary S, Zhornitsky S, Roy A, Summers C, Ahles T, Li C, Chao HH. The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity. Cancer Medicine 2022, 11: 3425-3436. PMID: 35315585, PMCID: PMC9487881, DOI: 10.1002/cam4.4704.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyMid-cingulate cortexEffects of ADTFunctional connectivityPrecentral gyrusN-back taskN-back performanceState functional connectivityMontreal Cognitive Assessment scoreHypothalamic functional connectivityProspective observational studyNonmetastatic prostate cancerProstate cancer patientsCognitive Assessment scoreQuality of lifeSustain attentionAffective functionsDeprivation therapyHypothalamic connectivityYears of educationAndrogen deprivationCorrect response rateQOL scoresCancer patientsClinical correlatesGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirlsCerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2021
Perceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults
Li G, Le TM, Wang W, Zhornitsky S, Chen Y, Chaudhary S, Zhu T, Zhang S, Bi J, Tang X, Li CR. Perceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults. NeuroImage Clinical 2021, 32: 102866. PMID: 34749288, PMCID: PMC8569726, DOI: 10.1016/j.nicl.2021.102866.Peer-Reviewed Original ResearchConceptsGray matter volumePerceived stressNeural markersRegional cortical thicknessCortical structuresAlcohol use behaviorsNon-binge drinkersHuman Connectome ProjectChronic alcohol exposure altersCortical thicknessVoxel-based morphometryEmotional distressConnectome ProjectDrinking menPath analysisCortical regionsDrinking womenBinge drinkingMatter volumeYoung adultsUse behaviorsStress regulationPCC thicknessBingeAlcohol exposure altersCognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis
Zhornitsky S, Chaudhary S, Le TM, Chen Y, Zhang S, Potvin S, Chao HH, van Dyck CH, Li CR. Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. Psychiatry Research Neuroimaging 2021, 317: 111380. PMID: 34482052, PMCID: PMC8579376, DOI: 10.1016/j.pscychresns.2021.111380.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlzheimer's diseaseHippocampal formationUse disordersHigher Clinical Dementia Rating Scale-SumVentricular volumeVolumetric deficitsCingulate cortexClinical Dementia Rating Scale SumCoordinating CenterSmaller hippocampal volumesLarger ventricular volumesNational Alzheimer's Coordinating CenterIsthmus cingulate cortexPosterior cingulate cortexMisuse of alcoholSuperior parietal cortexDistinct brain regionsCognitive dysfunctionHippocampal volumeInferior frontal gyrusRegional GMVHigh riskDementia severityDual diagnosis
2020
Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment
Chaudhary S, Kumaran S, Goyal V, Kalaivani M, Kaloiya G, Sagar R, Mehta N, Srivastava A, Jagannathan N. Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment. Neurological Sciences 2020, 42: 1053-1064. PMID: 32729012, DOI: 10.1007/s10072-020-04626-9.Peer-Reviewed Original ResearchConceptsFrontal gray matterParkinson's disease cognitive impairmentN-acetyl aspartateHealthy controlsGray matterCognitive impairmentMetabolic alterationsFrontal WMLC Model softwareProton magnetic resonance spectroscopic imagingFrontal white matter regionsCognitive biomarkersCholinergic neural transmissionPD-CN groupsMagnetic resonance spectroscopic imagingWhite matter regionsNeuro-metabolismPD dementiaFunctional impairmentPD-CIFunction lossNeural transmissionTotal creatineNormal cognitionTotal cholineCortical thickness and gyrification index measuring cognition in Parkinson’s disease
Chaudhary S, Kumaran S, Goyal V, Kaloiya G, Kalaivani M, Jagannathan N, Sagar R, Mehta N, Srivastava A. Cortical thickness and gyrification index measuring cognition in Parkinson’s disease. International Journal Of Neuroscience 2020, 131: 984-993. PMID: 32423354, DOI: 10.1080/00207454.2020.1766459.Peer-Reviewed Original ResearchConceptsHealthy controlsRegional cortical thicknessCortical thicknessGyrification indexCortical thinningDisease patientsGI reductionDesikan-Killiany atlasNormal healthy controlsPD-CNParkinson's disease patientsWidespread cortical thinningCortico-cortical connectivityClinical variablesPD-CIParkinson's diseaseDisease pathophysiologyNormal cognitionTemporal regionsROC analysisBrain surfaceAnatomical MRIBrain ROIsPatientsSuch alterationsDomain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment
Chaudhary S, Kumaran S, Kaloiya G, Goyal V, Sagar R, Kalaivani M, Jaganathan N, Mehta N, Srivastava A. Domain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment. Journal Of Clinical Neuroscience 2020, 75: 99-105. PMID: 32192853, DOI: 10.1016/j.jocn.2020.03.015.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentCognitive impairmentVisuospatial functionCognitive domain specificitySpecific cognitive impairmentsCognitive Assessment testMontreal Cognitive Assessment (MoCA) testStage of MCIExecutive functionPD clinical scoresDigit spanPD-MCIPD cognitionFronto-striatalRecall domainsDomain specificityCognitive AssessmentPD groupPotential confoundsCognitionCognitive pathophysiologyCortical syndromesCategorization of subjectsMemoryNormal cognition