2023
Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals
Dong X, Zhornitsky S, Wang W, Le T, Chen Y, Chaudhary S, Li C, Zhang S. Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. The International Journal Of Neuropsychopharmacology 2023, 26: 627-638. PMID: 37579016, PMCID: PMC10519818, DOI: 10.1093/ijnp/pyac019.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityInferior frontal cortexCocaine-dependent individualsHealthy controlsVentral striatumCocaine useDorsal striatumAbstinent cocaine-dependent individualsCocaine misuseFunctional connectivityYears of drinkingLeft orbitofrontal cortexBIS-11 scoresRecent cocaine useLeft inferior frontal cortexDopaminergic deficitCortex connectivityFrontal cortexSeparate cohortHuman studiesSeverity of useAnimal studiesSecond cohortOrbitofrontal cortexBarratt Impulsivity Scale
2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscoresCerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2020
Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment
Chaudhary S, Kumaran S, Goyal V, Kalaivani M, Kaloiya G, Sagar R, Mehta N, Srivastava A, Jagannathan N. Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment. Neurological Sciences 2020, 42: 1053-1064. PMID: 32729012, DOI: 10.1007/s10072-020-04626-9.Peer-Reviewed Original ResearchConceptsFrontal gray matterParkinson's disease cognitive impairmentN-acetyl aspartateHealthy controlsGray matterCognitive impairmentMetabolic alterationsFrontal WMLC Model softwareProton magnetic resonance spectroscopic imagingFrontal white matter regionsCognitive biomarkersCholinergic neural transmissionPD-CN groupsMagnetic resonance spectroscopic imagingWhite matter regionsNeuro-metabolismPD dementiaFunctional impairmentPD-CIFunction lossNeural transmissionTotal creatineNormal cognitionTotal cholineCortical thickness and gyrification index measuring cognition in Parkinson’s disease
Chaudhary S, Kumaran S, Goyal V, Kaloiya G, Kalaivani M, Jagannathan N, Sagar R, Mehta N, Srivastava A. Cortical thickness and gyrification index measuring cognition in Parkinson’s disease. International Journal Of Neuroscience 2020, 131: 984-993. PMID: 32423354, DOI: 10.1080/00207454.2020.1766459.Peer-Reviewed Original ResearchConceptsHealthy controlsRegional cortical thicknessCortical thicknessGyrification indexCortical thinningDisease patientsGI reductionDesikan-Killiany atlasNormal healthy controlsPD-CNParkinson's disease patientsWidespread cortical thinningCortico-cortical connectivityClinical variablesPD-CIParkinson's diseaseDisease pathophysiologyNormal cognitionTemporal regionsROC analysisBrain surfaceAnatomical MRIBrain ROIsPatientsSuch alterations