2014
Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects
Gupta S, Lataillade M, Kyriakides TC, Chiarella J, St. John EP, Webb S, Moreno EA, Simen BB, Kozal MJ. Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects. Viruses 2014, 6: 3428-3437. PMID: 25256391, PMCID: PMC4189030, DOI: 10.3390/v6093428.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsDrug Resistance, ViralHIV InfectionsHIV-1HumansMutationMutation RateReverse Transcriptase InhibitorsConceptsNNRTI resistance mutationsMajor NNRTI-resistance mutationsResistance mutationsAntiretroviral-naïve subjectsARV-naïve HIVMajor NNRTI mutationsNNRTI-resistant variantsTreatment-naïve HIVHIV-1 variantsNon-nucleoside reverseMutational loadNaïve HIVNNRTI mutationsNNRTI resistanceVariant frequencyTrue burdenTherapeutic failureTreatment outcomesTreatment responseAa positionsHIVViral variantsFurther evaluationResistant variantsDeep sequencingDeep Sequencing of HIV: Clinical and Research Applications
Chabria SB, Gupta S, Kozal MJ. Deep Sequencing of HIV: Clinical and Research Applications. Annual Review Of Genomics And Human Genetics 2014, 15: 1-31. PMID: 24821496, DOI: 10.1146/annurev-genom-091212-153406.BooksMeSH KeywordsDrug Resistance, ViralGenome, ViralHigh-Throughput Nucleotide SequencingHIVHIV InfectionsHumansMutationConceptsHuman immunodeficiency virusAntiretroviral therapyDrug-resistant human immunodeficiency virusDrug-resistant HIV variantsCare antiretroviral therapyMaximal viral suppressionTreatment-naive individualsDrug resistance mutationsViral quasispeciesViral suppressionDrug selective pressureAntiretroviral agentsSensitive genotyping methodsTreatment failureHIV transmissionImmunodeficiency virusHIV variantsClinical careVaccine developmentViral variantsViral heterogeneityMolecular virologyLow-frequency variantsViral fitnessSequencing-based assays
2009
Hepatitis B Virus Infection in US Correctional Facilities: A Review of Diagnosis, Management, and Public Health Implications
Gupta S, Altice FL. Hepatitis B Virus Infection in US Correctional Facilities: A Review of Diagnosis, Management, and Public Health Implications. Journal Of Urban Health 2009, 86: 263-279. PMID: 19184447, PMCID: PMC2648882, DOI: 10.1007/s11524-008-9338-z.BooksMeSH KeywordsAdultClinical ProtocolsContinuity of Patient CareDrug Resistance, ViralFemaleHepatitis BHepatitis B virusHumansMaleMiddle AgedPrisonersPublic HealthUnited StatesConceptsChronic viral infectionsHepatitis B virus infectionB virus infectionReview of diagnosisHBV infectionViral infectionVirus infectionMedical careChronic HBV infectionChronic hepatitis BChronic medical conditionsComprehensive medical carePublic health burdenPublic health impactHigh-risk behaviorsPublic health implicationsProvision of vaccinationUS correctional facilitiesCorrectional settingsHBV vaccineHepatitis BViral hepatitisTreatment guidelinesChronic infectionChronic illness