2022
Decreased Myelin Content on Myelin Water Imaging and Correlation with Cognitive Performance in Adults with Perinatal HIV
Patel P, Vecchio A, Chen P, Chiarella J, Kolind S, Hoff M, Dvorak A, Vavasour I, Spudich S, Marra C, Paul R, Rane S. Decreased Myelin Content on Myelin Water Imaging and Correlation with Cognitive Performance in Adults with Perinatal HIV. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3970.Peer-Reviewed Original ResearchCognitive impairmentCerebral white matter injuryMyelin water fractionWhite matter injuryMyelin contentCohort of adultsPerinatal HIVPathologic substrateMyelin water imagingHIVPHIVAdultsCognitive performanceExecutive functionImpairmentWater imagingCognitive profileInjuryCohortMyelin waterMyelinationPathology
2021
Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study
Peng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study. Frontiers In Neurology 2021, 12: 741044. PMID: 34675873, PMCID: PMC8524436, DOI: 10.3389/fneur.2021.741044.Peer-Reviewed Original ResearchAcute ischemic strokeHospitalized COVID-19 patientsCOVID-19 patientsCOVID-19 cohortNeurologic symptomsPrior strokeIschemic strokeAIS patientsDerivation cohortControl cohortRisk of AISMultivariable logistic regression modelIschemic stroke riskCOVID-19 severityYale New Haven HealthLogistic regression modelsHospital presentationIndependent predictorsStroke riskMajor health systemsHigh riskPatientsYounger ageCohortStroke
2020
Cognitive disorders in people living with HIV
Winston A, Spudich S. Cognitive disorders in people living with HIV. The Lancet HIV 2020, 7: e504-e513. PMID: 32621876, DOI: 10.1016/s2352-3018(20)30107-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCognitive disordersHIV reservoirConcomitant medication useLatent HIV reservoirCohort of peopleSuch cognitive disordersHigh rateMedication useExact prevalenceHIVCognitive functionBrain compartmentsDisordersOverall wellbeingSuch interventionsInterventionReduced ratesComorbiditiesCohortPrevalenceImpairment