2009
Structural basis of ligand binding by a c-di-GMP riboswitch
Smith KD, Lipchock SV, Ames TD, Wang J, Breaker RR, Strobel SA. Structural basis of ligand binding by a c-di-GMP riboswitch. Nature Structural & Molecular Biology 2009, 16: 1218-1223. PMID: 19898477, PMCID: PMC2850612, DOI: 10.1038/nsmb.1702.Peer-Reviewed Original Research
2001
Biochemical Detection of Monovalent Metal Ion Binding Sites within RNA
Basu S, Strobel S. Biochemical Detection of Monovalent Metal Ion Binding Sites within RNA. Methods 2001, 23: 264-275. PMID: 11243839, DOI: 10.1006/meth.2000.1137.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCationsElectrophoresis, Polyacrylamide GelGuanosineIonsMetalsModels, MolecularNucleic Acid ConformationRNAThionucleosidesConceptsX-ray crystal structureMonovalent cationsMetal ion binding siteMetal ion bindingHeavy metal cationsIon binding siteMetal sitesMetal cationsSoft LewisCrystal structureIon bindingCationsChemical propertiesNucleotide analog interference mappingP4-P6 domainAzoarcus group I intronMetal potassiumSimilar binding sitesNucleic acidsBinding sitesBiochemical detectionTetrahymena group I intronLarge RNAsGroup I intronDistinct biochemical signatures
2000
A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme11Edited by D. Draper
Strauss-Soukup J, Strobel S. A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme11Edited by D. Draper. Journal Of Molecular Biology 2000, 302: 339-358. PMID: 10970738, DOI: 10.1006/jmbi.2000.4056.Peer-Reviewed Original Research
1998
A minor groove RNA triple helix within the catalytic core of a group I intron
Szewczak A, Ortoleva-Donnelly L, Ryder S, Moncoeur E, Strobel S. A minor groove RNA triple helix within the catalytic core of a group I intron. Nature Structural & Molecular Biology 1998, 5: 1037-1042. PMID: 9846872, DOI: 10.1038/4146.Peer-Reviewed Original ResearchThe chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.
Ortoleva-Donnelly L, Szewczak A, Gutell R, Strobel S. The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme. RNA 1998, 4: 498-519. PMID: 9582093, PMCID: PMC1369635, DOI: 10.1017/s1355838298980086.Peer-Reviewed Original ResearchRibozyme chemogenetics
Strobel S. Ribozyme chemogenetics. Biopolymers 1998, 48: 65-81. PMID: 9846125, DOI: 10.1002/(sici)1097-0282(1998)48:1<65::aid-bip7>3.0.co;2-d.Peer-Reviewed Original ResearchMeSH KeywordsModels, MolecularMutagenesis, Site-DirectedNucleic Acid ConformationNucleotide MappingRNA, CatalyticConceptsHelix-helix packing interactionsDNA-protein interactionsLarge catalytic RNAsSingle-site substitutionsRibozyme catalytic coreTetrahymena group ICatalytic coreTertiary hydrogen bondsCatalytic RNAGenetic revertantsReceptor motifRibozyme functionPacking interactionsChemogenetic approachChemical correlatesReview ISuppressorGenetic analogyRevertantsTriple helixChemical basisNucleotide analoguesModification experimentsMutagenesisRNA
1997
RNA seeing double: Close-packing of helices in RNA tertiary structure
Strobel S, Doudna J. RNA seeing double: Close-packing of helices in RNA tertiary structure. Trends In Biochemical Sciences 1997, 22: 262-266. PMID: 9255068, DOI: 10.1016/s0968-0004(97)01056-6.Peer-Reviewed Original ResearchMeSH KeywordsBase CompositionModels, MolecularMolecular StructureNucleic Acid ConformationProteinsRNAConceptsHigher-order structure formationPacking of helicesChromosome maintenanceNoncanonical base pairsRNA processingDouble-helical segmentsRNA tertiary structureProtein biosynthesisRecognition motifRNA moleculesTertiary structureBase pairsHelical packingRNAEssential roleProteinActive siteBiosynthesisComplex architectureFoldingMotifHelixAssemblyDifferent strategies
1994
Translocation of an RNA duplex on a ribozyme
Strobel S, Cech T. Translocation of an RNA duplex on a ribozyme. Nature Structural & Molecular Biology 1994, 1: 13-17. PMID: 7544680, DOI: 10.1038/nsb0194-13.Peer-Reviewed Original Research