2009
Structural basis of ligand binding by a c-di-GMP riboswitch
Smith KD, Lipchock SV, Ames TD, Wang J, Breaker RR, Strobel SA. Structural basis of ligand binding by a c-di-GMP riboswitch. Nature Structural & Molecular Biology 2009, 16: 1218-1223. PMID: 19898477, PMCID: PMC2850612, DOI: 10.1038/nsmb.1702.Peer-Reviewed Original ResearchStructural and Chemical Basis for Glucosamine 6-Phosphate Binding and Activation of the glmS Ribozyme
Cochrane JC, Lipchock SV, Smith KD, Strobel SA. Structural and Chemical Basis for Glucosamine 6-Phosphate Binding and Activation of the glmS Ribozyme. Biochemistry 2009, 48: 3239-3246. PMID: 19228039, PMCID: PMC2854835, DOI: 10.1021/bi802069p.Peer-Reviewed Original Research
2008
A relaxed active site after exon ligation by the group I intron
Lipchock SV, Strobel SA. A relaxed active site after exon ligation by the group I intron. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5699-5704. PMID: 18408159, PMCID: PMC2311373, DOI: 10.1073/pnas.0712016105.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCrystallography, X-RayExonsHydrogen BondingIntronsKineticsMetalsPolynucleotide LigasesRNARNA SplicingThermodynamicsConceptsActive siteMetal ionsRelaxed active siteActive site metal ionScissile phosphateDirect metal coordinationHydrogen bonding contactsMetal coordinationBonding contactsTransition stateCrystal structureThermodynamic measurementsIonsGround stateStructureCoordinationStructural observationsTertiary interactionsIntron releaseExon ligationGroup I intronPhosphateComplexesReactionSecond step
2006
Structural Investigation of the GlmS Ribozyme Bound to Its Catalytic Cofactor
Cochrane JC, Lipchock SV, Strobel SA. Structural Investigation of the GlmS Ribozyme Bound to Its Catalytic Cofactor. Cell Chemical Biology 2006, 14: 97-105. PMID: 17196404, PMCID: PMC1847778, DOI: 10.1016/j.chembiol.2006.12.005.Peer-Reviewed Original Research
2001
The hairpin's turn
Strobel S, Ryder S. The hairpin's turn. Nature 2001, 410: 761-762. PMID: 11298426, DOI: 10.1038/35071209.Peer-Reviewed Original Research
1998
A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor
Basu S, P. Rambo R, Strauss-Soukup J, H.Cate J, R. Ferré-D´Amaré A, Strobel S, Doudna J. A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor. Nature Structural & Molecular Biology 1998, 5: 986-992. PMID: 9808044, DOI: 10.1038/2960.Peer-Reviewed Original ResearchConceptsP4-P6 domainTetraloop receptorCatalytic RNALarge catalytic RNAsGroup I intronRNA tertiary structure formationTertiary structure formationTertiary structural motifsI intronRNAWide diversityFoldingStructural motifsDivalent metal ionsPotassium ionsReceptorsIntronsAzoarcusDomainDiversityMotifSitesActivityMonovalent ions