1991
Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation
Strobel S, Dervan P. Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation. Nature 1991, 350: 172-174. PMID: 1848684, DOI: 10.1038/350172a0.Peer-Reviewed Original ResearchConceptsTriple helix formationGenomic DNABase pairsYeast genomic DNAHelix formationSequence-specific DNALarge genomic DNAGenomic libraryMegabase pairsPhysical mappingEnzymatic cleavageRecognition motifSpecificity of bindingChromosomal DNARestriction endonuclease digestionManageable fragmentsRecognition sequenceGenetic markersDNA showRestriction enzymesQuantitative cleavageLarge DNADNAEndonuclease digestionChromosomes
1990
Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation
Strobel S, Dervan P. Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation. Science 1990, 249: 73-75. PMID: 2195655, DOI: 10.1126/science.2195655.Peer-Reviewed Original Research