2008
A relaxed active site after exon ligation by the group I intron
Lipchock SV, Strobel SA. A relaxed active site after exon ligation by the group I intron. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5699-5704. PMID: 18408159, PMCID: PMC2311373, DOI: 10.1073/pnas.0712016105.Peer-Reviewed Original ResearchConceptsActive siteMetal ionsRelaxed active siteActive site metal ionScissile phosphateDirect metal coordinationHydrogen bonding contactsMetal coordinationBonding contactsTransition stateCrystal structureThermodynamic measurementsIonsGround stateStructureCoordinationStructural observationsTertiary interactionsIntron releaseExon ligationGroup I intronPhosphateComplexesReactionSecond step
2000
A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme11Edited by D. Draper
Strauss-Soukup J, Strobel S. A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme11Edited by D. Draper. Journal Of Molecular Biology 2000, 302: 339-358. PMID: 10970738, DOI: 10.1006/jmbi.2000.4056.Peer-Reviewed Original Research[6] Chemical probing of RNA by nucleotide analog interference mapping
Ryder S, Ortoleva-Donnelly L, Kosek A, Strobel S. [6] Chemical probing of RNA by nucleotide analog interference mapping. Methods In Enzymology 2000, 317: 92-109. PMID: 10829274, DOI: 10.1016/s0076-6879(00)17008-9.Peer-Reviewed Original Research
1998
A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor
Basu S, P. Rambo R, Strauss-Soukup J, H.Cate J, R. Ferré-D´Amaré A, Strobel S, Doudna J. A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor. Nature Structural & Molecular Biology 1998, 5: 986-992. PMID: 9808044, DOI: 10.1038/2960.Peer-Reviewed Original ResearchConceptsP4-P6 domainTetraloop receptorCatalytic RNALarge catalytic RNAsGroup I intronRNA tertiary structure formationTertiary structure formationTertiary structural motifsI intronRNAWide diversityFoldingStructural motifsDivalent metal ionsPotassium ionsReceptorsIntronsAzoarcusDomainDiversityMotifSitesActivityMonovalent ionsComplementary sets of noncanonical base pairs mediate RNA helix packing in the group I intron active site
Strobel S, Ortoleva-Donnelly L, Ryder S, Cate J, Moncoeur E. Complementary sets of noncanonical base pairs mediate RNA helix packing in the group I intron active site. Nature Structural & Molecular Biology 1998, 5: 60-66. PMID: 9437431, DOI: 10.1038/nsb0198-60.Peer-Reviewed Original Research
1996
Three recognition events at the branch‐site adenine.
Query C, Strobel S, Sharp P. Three recognition events at the branch‐site adenine. The EMBO Journal 1996, 15: 1392-1402. PMID: 8635472, PMCID: PMC450044, DOI: 10.1002/j.1460-2075.1996.tb00481.x.Peer-Reviewed Original ResearchExocyclic Amine of the Conserved G·U Pair at the Cleavage Site of the Tetrahymena Ribozyme Contributes to 5‘-Splice Site Selection and Transition State Stabilization †
Strobel S, Cech T. Exocyclic Amine of the Conserved G·U Pair at the Cleavage Site of the Tetrahymena Ribozyme Contributes to 5‘-Splice Site Selection and Transition State Stabilization †. Biochemistry 1996, 35: 1201-1211. PMID: 8573575, DOI: 10.1021/bi952244f.Peer-Reviewed Original Research
1995
Minor Groove Recognition of the Conserved G⋅U Pair at the Tetrahymena ribozyme Reaction Site
Strobel S, Cech T. Minor Groove Recognition of the Conserved G⋅U Pair at the Tetrahymena ribozyme Reaction Site. Science 1995, 267: 675-679. PMID: 7839142, DOI: 10.1126/science.7839142.Peer-Reviewed Original ResearchThe branch site adenosine is recognized differently for the two steps of pre-mRNA splicing.
Query C, Strobel S, Sharp P. The branch site adenosine is recognized differently for the two steps of pre-mRNA splicing. Nucleic Acids Symposium Series 1995, 224-5. PMID: 8643377.Peer-Reviewed Original Research