1997
RNA seeing double: Close-packing of helices in RNA tertiary structure
Strobel S, Doudna J. RNA seeing double: Close-packing of helices in RNA tertiary structure. Trends In Biochemical Sciences 1997, 22: 262-266. PMID: 9255068, DOI: 10.1016/s0968-0004(97)01056-6.Peer-Reviewed Original ResearchConceptsHigher-order structure formationPacking of helicesChromosome maintenanceNoncanonical base pairsRNA processingDouble-helical segmentsRNA tertiary structureProtein biosynthesisRecognition motifRNA moleculesTertiary structureBase pairsHelical packingRNAEssential roleProteinActive siteBiosynthesisComplex architectureFoldingMotifHelixAssemblyDifferent strategies
1991
Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation
Strobel S, Dervan P. Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation. Nature 1991, 350: 172-174. PMID: 1848684, DOI: 10.1038/350172a0.Peer-Reviewed Original ResearchConceptsTriple helix formationGenomic DNABase pairsYeast genomic DNAHelix formationSequence-specific DNALarge genomic DNAGenomic libraryMegabase pairsPhysical mappingEnzymatic cleavageRecognition motifSpecificity of bindingChromosomal DNARestriction endonuclease digestionManageable fragmentsRecognition sequenceGenetic markersDNA showRestriction enzymesQuantitative cleavageLarge DNADNAEndonuclease digestionChromosomes