2002
Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp
Travi BL, Osorio Y, Melby PC, Chandrasekar B, Arteaga L, Saravia NG. Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp. Infection And Immunity 2002, 70: 2288-2296. PMID: 11953362, PMCID: PMC127932, DOI: 10.1128/iai.70.5.2288-2296.2002.Peer-Reviewed Original ResearchConceptsFemale animalsGender-related differencesMale animalsImmune responseInterleukin-4Lesion sizeDistant cutaneous sitesPermissive immune responsePrepubertal male animalsSevere cutaneous lesionsSex hormone statusLeishmania sppTGF-beta mRNASeverity of diseaseAdult male animalsGreater lesion sizeGrowth factor betaGreater parasite burdenIntralesional expressionCutaneous sitesIL-10Lymph nodesChronic lesionsClinical evolutionCutaneous infections
1993
Epidemiology of Cutaneous Leishmaniasis in Colombia: A Longitudinal Study of the Natural History, Prevalence, and Incidence of Infection and Clinical Manifestations
Weigle K, Santrich C, Martinez F, Valderrama L, Saravia N. Epidemiology of Cutaneous Leishmaniasis in Colombia: A Longitudinal Study of the Natural History, Prevalence, and Incidence of Infection and Clinical Manifestations. The Journal Of Infectious Diseases 1993, 168: 699-708. PMID: 8354912, DOI: 10.1093/infdis/168.3.699.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAnimalsAntigens, ProtozoanChildChild, PreschoolCohort StudiesColombiaFemaleHumansIncidenceInfantInfant, NewbornLeishmania braziliensisLeishmaniasis, CutaneousLongitudinal StudiesMaleMiddle AgedModels, BiologicalProspective StudiesRespiratory SystemRural PopulationSex FactorsSkinSkin TestsTime FactorsConceptsLeishmanin skin test conversionMost primary infectionsSkin test conversionBurden of diseaseIncidence of infectionLeishmaniasis control programClinical manifestationsProspective studyPrimary infectionTest conversionLeishmania infectionIncidence rateTypical scarCutaneous leishmaniasisEndemic areasNew infectionsLeishmaniasis casesNatural historyInfectionLeishmaniasisNaive hostsLongitudinal studyLesionsOne-thirdIncidenceEpidemiology of Cutaneous Leishmaniasis in Colombia: Environmental and Behavioral Risk Factors for Infection, Clinical Manifestations, and Pathogenicity
Weigle K, Santrich C, Martinez F, Valderrama L, Saravia N. Epidemiology of Cutaneous Leishmaniasis in Colombia: Environmental and Behavioral Risk Factors for Infection, Clinical Manifestations, and Pathogenicity. The Journal Of Infectious Diseases 1993, 168: 709-714. PMID: 8354913, DOI: 10.1093/infdis/168.3.709.Peer-Reviewed Original ResearchConceptsRisk factorsFarming occupationLeishmania panamensis infectionRisk factor informationBehavioral risk factorsAcquisition of infectionYears of ageRisk of lesionsPanamensis infectionLeishmanial lesionsClinical manifestationsMale sexActive surveillanceLeishmania infectionCase ascertainmentCutaneous leishmaniasisNew infectionsInfectionLeishmania braziliensisLesionsFactor informationStrongest predictorAgeLeishmaniasisSex