2011
Leishmania (Viannia) Infection in the Domestic Dog in Chaparral, Colombia
Santaella J, Ocampo CB, Saravia NG, Méndez F, Góngora R, Gomez MA, Munstermann LE, Quinnell RJ. Leishmania (Viannia) Infection in the Domestic Dog in Chaparral, Colombia. American Journal Of Tropical Medicine And Hygiene 2011, 84: 674-680. PMID: 21540374, PMCID: PMC3083732, DOI: 10.4269/ajtmh.2011.10-0159.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisSkin biopsy specimensHuman cutaneous leishmaniasisReservoirs of LeishmaniaEnzyme-linked immunosorbentAmerican cutaneous leishmaniasisPrevalence of infectionBiopsy specimensLeishmania infectionRisk factorsCanine infectionLeishmania guyanensisBuffy coatL. braziliensisDogsInfectionLeishmaniasisPeridomestic transmissionL. guyanensisPositive resultsBlottingMore testsDomestic dogsGuyanensisBiopsy
2009
Role of Toll-like receptors in the response of human macrophages to Leishmania panamensis infection (133.17)
Gallego C, Saravia N, Valderrama L, Golenbock D. Role of Toll-like receptors in the response of human macrophages to Leishmania panamensis infection (133.17). The Journal Of Immunology 2009, 182: 133.17-133.17. DOI: 10.4049/jimmunol.182.supp.133.17.Peer-Reviewed Original ResearchToll-like receptorsOutcome of infectionPanamensis infectionHuman macrophagesTLR ligandsL. panamensisExpression of TLR1L. panamensis infectionsLeishmania panamensis infectionActivation of TLR2Production of TNFαAmerican cutaneous leishmaniasisHuman primary macrophagesL. panamensis promastigotesPossible roleHealthy donorsCutaneous leishmaniasisTNFα productionInnate recognitionWild-type (WT) mouse macrophagesInfectionPrimary macrophagesTLR2MacrophagesPhagocytic cells
2008
Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia.
Rodríguez-Barraquer I, Góngora R, Prager M, Pacheco R, Montero LM, Navas A, Ferro C, Miranda MC, Saravia NG. Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia. American Journal Of Tropical Medicine And Hygiene 2008, 78: 276-82. PMID: 18256429, DOI: 10.4269/ajtmh.2008.78.276.Peer-Reviewed Original ResearchConceptsAmerican cutaneous leishmaniasisCutaneous leishmaniasisEtiologic agentLeishmania guyanensisProbable etiologic agentLeishmaniasis control programLarge epidemicsMonoclonal antibodiesLeishmania isolatesLeishmaniasisPeridomestic settingsZoonotic diseaseL. panamensisEpidemicDomestic transmissionControl programsPresent studyIsoenzyme electrophoresisIsolatesAgentsGuyanensisPatientsDiseaseDiagnosisAntibodies
2006
Evidence for Leishmania (Viannia) Parasites in the Skin and Blood of Patients Before and After Treatment
Vergel C, Palacios R, Cadena H, Posso CJ, Valderrama L, Perez M, Walker J, Travi BL, Saravia NG. Evidence for Leishmania (Viannia) Parasites in the Skin and Blood of Patients Before and After Treatment. The Journal Of Infectious Diseases 2006, 194: 503-511. PMID: 16845635, DOI: 10.1086/505583.Peer-Reviewed Original ResearchConceptsPeripheral blood monocytesAmerican cutaneous leishmaniasisCutaneous leishmaniasisLeishmania parasitesUnaffected skinAnthroponotic transmissionAcquisition of infectionBlood of patientsSource of infectionSand fliesAdult patientsLesion scarTreatment failureAntimonial drugsPatientsNormal skinLeishmaniasisMonocytesZoonotic diseaseLesion bordersSkinTreatmentMolecular detection methodsPositive resultsInfectionResistance to Antimony and Treatment Failure in Human Leishmania (Viannia) Infection
Rojas R, Valderrama L, Valderrama M, Varona MX, Ouellette M, Saravia NG. Resistance to Antimony and Treatment Failure in Human Leishmania (Viannia) Infection. The Journal Of Infectious Diseases 2006, 193: 1375-1383. PMID: 16619185, DOI: 10.1086/503371.Peer-Reviewed Original ResearchConceptsTreatment failureMeglumine antimoniatePrimary resistanceAntimonial drugsSecondary resistanceDrug resistanceHuman Leishmania infectionsEffective immune responseAnthroponotic visceral leishmaniasisAmerican cutaneous leishmaniasisAntimonial therapyStandard treatmentCutaneous diseaseLeishmania infectionTherapeutic responseImmune responseCutaneous leishmaniasisVisceral leishmaniasisAnthroponotic transmissionResistant organismsEffective doseIntracellular amastigotesSusceptible strainsAntimoniatePatients