2000
Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series
Casson P, Lindsay M, Pisarska M, Carson S, Buster J. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Human Reproduction 2000, 15: 2129-2132. PMID: 11006185, DOI: 10.1093/humrep/15.10.2129.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotrophinOvarian stimulationDHEA treatmentPoor respondersPoor responseInsulin-like growth factor-1 effectsGrowth hormonePg/Healthy non-smoking womenDay 3 FSHOvarian stimulation responseOvarian stimulation cyclesNon-smoking womenPeak oestradiol concentrationsGonadotrophin doseDehydroepiandrosterone administrationGonadotrophin administrationOvarian responseCase seriesTwin pregnanciesMIU/Intrauterine inseminationOestradiol concentrationsFollicular maturityChorionic gonadotrophin
1998
Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial
Casson P, Santoro N, Elkind-Hirsch K, Carson S, Hornsby P, Abraham G, Buster J. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial. Fertility And Sterility 1998, 70: 107-110. PMID: 9660430, DOI: 10.1016/s0015-0282(98)00121-6.Peer-Reviewed Original ResearchConceptsHigh-density lipoproteinInsulin-like growth factorLevels of DHEADHEA therapySerum DHEAImmune indicesFree insulin-like growth factorDual-energy X-ray absorptiometry scanX-ray absorptiometry scansA1 levelsGrowth factorLiver function testsInsulin-sensitizing propertiesRatio of IGFSmall study sizeSix-month trialPostdose levelsPremenopausal rangePostmenopausal womenIGFBP-3Function testsInsulin sensitivityReferral practicesParallel trialMAIN OUTCOME
1997
Effect of postmenopausal estrogen replacement on circulating androgens.
Casson P, Elkind-Hirsch K, Buster J, Hornsby P, Carson S, Snabes M. Effect of postmenopausal estrogen replacement on circulating androgens. Obstetrics And Gynecology 1997, 90: 995-8. PMID: 9397118, DOI: 10.1016/s0029-7844(97)00538-3.Peer-Reviewed Original ResearchConceptsEstrogen replacement therapyMenopausal estrogen replacement therapySerum androgen levelsPostmenopausal womenReplacement therapySex hormonesAndrogen levelsPlacebo-controlled crossover studyAdrenal androgen deficiencyMean serum E2Postmenopausal estrogen replacementEstrogen replacementSerum dehydroepiandrosteroneAndrogen deficiencyBioavailable testosteroneSerum E2Crossover studyTreatment armsAndrogen replacementAdrenal effectsPrevious randomizedPg/Micrograms/TestosteroneSerum samples
1996
Ovarian hyperstimulation augments adrenal dehydroepiandrosterone sulfate secretion**Supported in part by the American College of Obstetricians and Gynecologists-Ortho Academic Training Fellowship, of which Dr. Casson is the 1990-1991 recipient ††Presented in part at the Annual Meetings of the Canadian Fertility and Andrology Society, Quebec, Quebec, Canada, September 11 to 14, 1991; and Kananaskis, alberta, Canada, November 25 to 28, 1992
Casson P, Kristiansen S, Umstot E, Carson S, Buster J. Ovarian hyperstimulation augments adrenal dehydroepiandrosterone sulfate secretion**Supported in part by the American College of Obstetricians and Gynecologists-Ortho Academic Training Fellowship, of which Dr. Casson is the 1990-1991 recipient ††Presented in part at the Annual Meetings of the Canadian Fertility and Andrology Society, Quebec, Quebec, Canada, September 11 to 14, 1991; and Kananaskis, alberta, Canada, November 25 to 28, 1992. Fertility And Sterility 1996, 65: 950-953. PMID: 8612855, DOI: 10.1016/s0015-0282(16)58267-3.Peer-Reviewed Original ResearchConceptsOvarian hyperstimulationHyperstimulation cyclesSerum DHEAStandard ACTH testAdrenal androgen secretionSerum DHEAS levelsOvarian hyperstimulation cyclesProspective clinical studyMain outcome measuresPeak of stimulationDHEAS secretionOvulatory infertilityACTH testInfertile womenF secretionAndrogen secretionCanadian FertilityAndrology SocietyDHEAS levelsInfertility clinicNormal womenE2 levelsIntrapatient variabilityClinical studiesOutcome measuresDelivery of dehydroepiandrosterone to premenopausal women: Effects of micronization and nonoral administration
Casson P, Straughn A, Umstot E, Abraham G, Carson S, Buster J. Delivery of dehydroepiandrosterone to premenopausal women: Effects of micronization and nonoral administration. American Journal Of Obstetrics And Gynecology 1996, 174: 649-653. PMID: 8623801, DOI: 10.1016/s0002-9378(96)70444-1.Peer-Reviewed Original ResearchConceptsSerum dehydroepiandrosteroneDehydroepiandrosterone sulfateSingle-dose studySingle-dose comparisonVaginal dehydroepiandrosteronePremenopausal womenOral dehydroepiandrosteroneVaginal dosesNonoral administrationTestosterone levelsBlood samplingVaginal administrationCurve ratioDehydroepiandrosteroneTestosteronePhysiologic levelsAdministrationDosesDelivery methodsKeuls testStudent-NewmanHoursEffect of micronizationPlaceboSulfate/Androgen replacement therapy in women: myths and realities.
Casson P, Carson S. Androgen replacement therapy in women: myths and realities. International Journal Of Fertility And Women's Medicine 1996, 41: 412-22. PMID: 8894799.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdrenal GlandsAgingAndrogensCognitionDehydroepiandrosteroneEstrogen Replacement TherapyFemaleHumansImmune SystemMenopauseSex CharacteristicsConceptsAndrogen replacementMenopausal womenAndrogen replacement therapyGrowth hormone axisLong-term trialsProlonged therapyAdrenal androgensTestosterone replacementReplacement therapyNatural menopauseHormone axisClinical investigationSide effectsDeficiency statesImmune systemPhysiologic levelsWomenTherapyPotential benefitsPreliminary studyReplacementMenopauseDHEAAndrogensTrials