Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release
Mishra S, Kannan S. Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release. ACS Biomaterials Science & Engineering 2017, 3: 3607-3619. PMID: 33445395, DOI: 10.1021/acsbiomaterials.7b00498.Peer-Reviewed Original ResearchBimetallic nanoparticlesMicrowave-assisted polyol synthesisPH-sensitive hydrazone linkageDrug releaseResponsive drug releaseNegligible drug releaseOne-pot synthesisBimetallic silverCancer theranosisContrast abilityCapping agentPolyol synthesisAverage sizeHydrazone linkagePotential anticancer drugsAcidic mediumContrast performanceOptical imagingParamagnetic behaviorPhysiological pHMolar ratioChitosanAnticancer drugsAgDOXA Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy
Mishra SK, Kannan S. A Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy. Inorganic Chemistry 2017, 56: 12054-12066. PMID: 28933536, DOI: 10.1021/acs.inorgchem.7b02103.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAntineoplastic AgentsChitosanContrast MediaDrug CarriersDrug LiberationGreen Chemistry TechnologyHeatingHeLa CellsHumansMagnetic Resonance ImagingMetal NanoparticlesMultimodal ImagingNeodymiumOptical ImagingPaclitaxelParticle SizeSilverTheranostic NanomedicineTomography, X-Ray ComputedConceptsChemo-photothermal therapyPhotothermal effectMicrowave-assisted polyol synthesisCombined chemo-photothermal therapyMRI/CT imagingEfficient photothermal effectHigh loading efficiencyLoading of paclitaxelTheranostic nanoparticlesBimetallic nanoparticlesMetallic nanostructuresGood monodispersityPolyol synthesisNIR laserLoading efficiencyAverage sizeNanoparticlesGood biocompatibilityMultimodal imagingInfrared regionExcellent candidateNIR imagingChitosan functionalizationSynergistic effectDrug molecules