Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice
Carson C, Macias-Velasco JF, Gunawardana S, Miranda MA, Oyama S, St. Pierre CL, Schmidt H, Wayhart JP, Lawson HA. Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice. Cell Reports 2020, 33: 108237. PMID: 33027654, PMCID: PMC7594587, DOI: 10.1016/j.celrep.2020.108237.Peer-Reviewed Original ResearchConceptsJ miceGlycemic dysfunctionSM/J miceGlycemic controlAdipose expansionImpairs insulin sensitivityBrown adipose depotsHigh-fat dietPoor glucose homeostasisWeeks of ageMetabolic complicationsPersistent obesityInsulin sensitivityGlucose homeostasisAdipose depotsInnovative therapiesDysfunctionObesityMiceRemissionGlucose sinkTranscriptomic changesComplicationsTherapy