Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
Kim H, Park C, Ho S, Lee J, Lee S, Kim Y, Rah J, Jeong S, Suh Y. Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. The FASEB Journal 2000, 14: 1508-1517. DOI: 10.1096/fj.99-0809com.Peer-Reviewed Original ResearchAmyloid precursor proteinGlutamate-induced excitotoxicityAlzheimer amyloid precursor proteinPrimary cortical neuronsSK-N-SHCalcium homeostasisAlzheimer's diseaseNeuronal cellsCortical neuronsRecombinant carboxy-terminal 105 amino acid fragmentPC-12 cellsCarboxyl-terminal fragmentRat primary cortical neuronsSK-N-SH cellsIntracellular calcium concentrationLong-term potentiationNeurotoxicity characteristicNeuropathological changesMK-801Rat hippocampusAmyloid β-peptideAβ1-42ExcitotoxicityCalcium increaseInward currents