2011
The crystal structure of GXGD membrane protease FlaK
Hu J, Xue Y, Lee S, Ha Y. The crystal structure of GXGD membrane protease FlaK. Nature 2011, 475: 528-531. PMID: 21765428, PMCID: PMC3894692, DOI: 10.1038/nature10218.Peer-Reviewed Original ResearchConceptsFamily of proteasesFirst crystal structureIntramembrane proteasesPrepilin peptidaseMethanococcus maripaludisMembrane proteasePreflagellin peptidaseFamilial Alzheimer's diseaseVirulence factorsAspartyl proteaseBiochemical analysisProteasePathogenic bacteriaStructural knowledgePresenilinPeptidaseCrystal structureSoluble counterpartActive siteFamilyRational designAspartylBacteriaAlzheimer's diseaseFundamental differences
2000
Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
Kim H, Park C, Ho S, Lee J, Lee S, Kim Y, Rah J, Jeong S, Suh Y. Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. The FASEB Journal 2000, 14: 1508-1517. DOI: 10.1096/fj.99-0809com.Peer-Reviewed Original ResearchAmyloid precursor proteinGlutamate-induced excitotoxicityAlzheimer amyloid precursor proteinPrimary cortical neuronsSK-N-SHCalcium homeostasisAlzheimer's diseaseNeuronal cellsCortical neuronsRecombinant carboxy-terminal 105 amino acid fragmentPC-12 cellsCarboxyl-terminal fragmentRat primary cortical neuronsSK-N-SH cellsIntracellular calcium concentrationLong-term potentiationNeurotoxicity characteristicNeuropathological changesMK-801Rat hippocampusAmyloid β-peptideAβ1-42ExcitotoxicityCalcium increaseInward currents
1999
Comparison of the Structures of β Amyloid Peptide (25–35) and Substance P in Trifluoroethanol/Water Solution
Lee S, Suh Y, Kim S, Kim Y. Comparison of the Structures of β Amyloid Peptide (25–35) and Substance P in Trifluoroethanol/Water Solution. Journal Of Biomolecular Structure And Dynamics 1999, 17: 381-391. PMID: 10563586, DOI: 10.1080/07391102.1999.10508369.Peer-Reviewed Original ResearchConceptsSubstance PTrifluoroethanol/water solutionTachykinin familyAmyloid peptidesBrains of patientsHydrophobic side chainsBeta-amyloid peptideNMR spectroscopyAqueous solutionΒ-amyloid peptideAlpha-helical structureAromatic ringConformational featuresWater solutionSide chainsTachykinin receptorsBeta amyloidSenile plaquesAlzheimer's diseaseThree-dimensional structureDiseaseReceptors