2005
Melanocyte and Keratinocyte Carcinogenesis: p53 Family Protein Activities and Intersecting mRNA Expression Profiles
Kulesz-Martin M, Lagowski J, Fei S, Pelz C, Sears R, Powell MB, Halaban R, Johnson J. Melanocyte and Keratinocyte Carcinogenesis: p53 Family Protein Activities and Intersecting mRNA Expression Profiles. Journal Of Investigative Dermatology Symposium Proceedings 2005, 10: 142-152. PMID: 16363065, DOI: 10.1111/j.1087-0024.2005.200405.x.Peer-Reviewed Original Research
1993
Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis
Longley B, Morganroth G, Tyrrell L, Ding T, Anderson D, Williams D, Halaban R. Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis. New England Journal Of Medicine 1993, 328: 1302-1307. PMID: 7682288, DOI: 10.1056/nejm199305063281803.Peer-Reviewed Original ResearchConceptsMast cell growth factorMessenger RNAGrowth factorC-kit proto-oncogeneProduction of melaninSoluble formGrowth factor geneFactor genesProteolytic processingProto-oncogeneSequence abnormalitiesExtracellular spaceAltered metabolismAltered distributionGrowth factor messenger RNASkin of patientsDermal cellsCellsPolymerase chain reactionCutaneous mastocytosisMast cells
1989
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.
Dotto G, Moellmann G, Ghosh S, Edwards M, Halaban R. Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. Journal Of Cell Biology 1989, 109: 3115-3128. PMID: 2556408, PMCID: PMC2115972, DOI: 10.1083/jcb.109.6.3115.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorMurine melanocytesTransformation of melanocytesNormal murine melanocytesMetastatic melanoma cellsSynthesis of melaninMelanotic phenotypeConstitutive expressionFibroblast growth factorOncogene MYCRespective transformantsTransformantsFactor cDNAFormation of tumorsReconstitution experimentsDifferentiated functionsRecombinant retrovirusExogenous basic fibroblast growth factorOncogeneAutonomous growthExpression of bFGFCDNAConstitutive productionNude miceMelanocytes