1993
White Mutants in Mice Shedding Light on Humans
Halaban R, Moellmann G. White Mutants in Mice Shedding Light on Humans. Journal Of Investigative Dermatology 1993, 100: s176-s185. DOI: 10.1038/jid.1993.73.Peer-Reviewed Original ResearchMembrane receptor tyrosine kinasesMouse mutant modelsPink-eyed dilutionDefective signal transductionReceptor kinase activityEnzyme activityC-kitDistinct enzyme activitiesIdentification of mutationsRespective enzyme activitiesPiebald phenotypeShares homologyLocus proteinSignal transductionKinase activityCatalase BMolecular geneticsTyrosine kinaseWhite mutantsMutant modelsHair melanocytesPoint mutationsTyrosinase-negative albinismNormal pigmentationProliferation of melanocytesWhite mutants in mice shedding light on humans.
Halaban R, Moellmann G. White mutants in mice shedding light on humans. Journal Of Investigative Dermatology 1993, 100: 176s-185s. PMID: 8433006, DOI: 10.1038/jid.1993.10.Peer-Reviewed Original ResearchConceptsMembrane receptor tyrosine kinasesMouse mutant modelsPink-eyed dilutionDefective signal transductionReceptor kinase activityEnzyme activityC-kitDistinct enzyme activitiesIdentification of mutationsRespective enzyme activitiesPiebald phenotypeShares homologyLocus proteinSignal transductionKinase activityCatalase BMolecular geneticsTyrosine kinaseWhite mutantsMutant modelsHair melanocytesDopachrome tautomerasePoint mutationsTyrosinase-negative albinismNormal pigmentation
1991
Growth factors and tyrosine protein kinases in normal and malignant melanocytes
Halaban R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer And Metastasis Reviews 1991, 10: 129-140. PMID: 1873853, DOI: 10.1007/bf00049410.Peer-Reviewed Original ResearchConceptsMast cell growth factorTyrosine kinase activityKinase activityBasic fibroblast growth factorNormal melanocyte proliferationTyrosine kinaseExogenous peptide growth factorsHepatocyte growth factorGrowth factorTyrosine protein kinaseAberrant gene expressionMelanocyte proliferationTransmembrane tyrosine kinaseReceptor tyrosine kinasesEnvironmental growth factorsNormal human melanocytesPeptide growth factorsMouse melanocytesProtein kinaseGrowth factor receptorUncontrolled growthC-kitGene expressionConstitutive expressionFibroblast growth factor