2019
Chapter 1 Essentiality of Omega-3 Polyunsaturated Fatty Acids for Mammalian Brain Development: A Translational Perspective
McNamara R, Asch R. Chapter 1 Essentiality of Omega-3 Polyunsaturated Fatty Acids for Mammalian Brain Development: A Translational Perspective. 2019, 3-20. DOI: 10.1016/b978-0-12-815238-6.00001-8.ChaptersLong-term neurocognitive benefitsNeurocognitive benefitsOmega-3 Polyunsaturated Fatty AcidsBrain developmentTerm-born infantsInfant neurocognitive developmentNonhuman primate studiesInfant brain developmentPolyunsaturated Fatty AcidsBrain DHAMaternal DHADHA supplementationMammalian brain developmentFatty acidsNeurodevelopmental abnormalitiesTranslational evidencePerinatal developmentMammalian brainNeurocognitive developmentHuman mothersPrimate studiesRobust reductionInfantsTranslational perspectiveDHA
2017
Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study
McNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.Peer-Reviewed Original ResearchConceptsWhite matter integrityDEF ratsRight external capsuleTract-based spatial statisticsGreater radial diffusivityCON ratsExternal capsuleProinflammatory signalingDiffusion tensor imagingProinflammatory markersRadial diffusivityFO ratsMyelin basic protein mRNA expressionLower CRP levelsDiffusion tensor imaging studyVoxelwise tract-based spatial statisticsBrain white matter integrityWhite matter microstructural integrityCorpus callosum genuProtein mRNA expressionBrain DHAPeriadolescent developmentCRP levelsFatty acidsMale ratsGlutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study
McNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study. Psychiatry Research Neuroimaging 2017, 270: 39-45. PMID: 29049903, PMCID: PMC5671887, DOI: 10.1016/j.pscychresns.2017.10.003.Peer-Reviewed Original ResearchConceptsDEF ratsGlutamate homeostasisPrefrontal cortexFO ratsDHA levelsAdult rat prefrontal cortexVivo 1H MRS studyMarkers of excitotoxicityFatty acid-deficient dietAstrocyte glutamate transportersH-MRS scansAdult rat brainRat prefrontal cortexAdult prefrontal cortexGlutamine/glutamate ratioDietary-induced alterationsMajor psychiatric disordersBrain DHAGlutamate levelsDiet groupGLAST expressionGlutamine synthetase expressionMRS scansAdolescent ratsRat brain