1999
Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites.
Blander J, Visintin I, Janeway C, Medzhitov R. Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites. The Journal Of Immunology 1999, 163: 3746-52. PMID: 10490970, DOI: 10.4049/jimmunol.163.7.3746.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-Galactoside alpha-2,3-SialyltransferaseCD4-Positive T-LymphocytesCell DifferentiationCell MovementDown-RegulationEpitopes, T-LymphocyteFucosyltransferasesGangliosidesHistocompatibility Antigens Class IIHypersensitivity, DelayedInterleukin-12Interleukin-4InterphaseLewis Blood Group AntigensLymph NodesLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, TransgenicPeptide FragmentsRNA, MessengerSialyl Lewis X AntigenSialyltransferasesTh1 CellsTh2 CellsUp-Regulation
1998
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides
Chervonsky A, Medzhitov R, Denzin L, Barlow A, Rudensky A, Janeway C. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10094-10099. PMID: 9707606, PMCID: PMC21467, DOI: 10.1073/pnas.95.17.10094.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAntigens, Differentiation, B-LymphocyteB-LymphocytesCarrier ProteinsCell MembraneDimerizationHistocompatibility Antigens Class IIMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMolecular Sequence DataProtein BindingProtein ConformationT-Lymphocytes
1997
The orientation of a T cell receptor to its MHC class II:peptide ligands.
Hong S, Sant'Angelo D, Dittel B, Medzhitov R, Yoon S, Waterbury P, Janeway C. The orientation of a T cell receptor to its MHC class II:peptide ligands. The Journal Of Immunology 1997, 159: 4395-402. PMID: 9379037, DOI: 10.4049/jimmunol.159.9.4395.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesClone CellsHistocompatibility Antigens Class IILigandsMicePeptidesReceptors, Antigen, T-Cell, alpha-betaStructure-Activity RelationshipConceptsMHC class II moleculesClass II moleculesComplementarity-determining region 1Self MHC class II moleculesCD4 T cellsMHC class IIT cell clonesMHC class II ligandsMHC class I.T cell receptorT cell linesCD4(-) TCRClass II ligandsD10 T cell cloneT cellsClass IICell receptorI-AkCell clonesClass I.ReceptorsCell linesTCRPresent study
1996
The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands
Sant'Angelo D, Waterbury G, Preston-Hurlburt P, Yoon S, Medzhitov R, Hong S, Janeway C. The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands. Immunity 1996, 4: 367-376. PMID: 8612131, DOI: 10.1016/s1074-7613(00)80250-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesDNAHistocompatibility Antigens Class IIHybridomasImmunizationLigandsMiceMice, TransgenicMolecular Sequence DataPeptidesReceptors, Antigen, T-Cell, alpha-betaT-Lymphocytes