1999
Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites.
Blander J, Visintin I, Janeway C, Medzhitov R. Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites. The Journal Of Immunology 1999, 163: 3746-52. PMID: 10490970, DOI: 10.4049/jimmunol.163.7.3746.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-Galactoside alpha-2,3-SialyltransferaseCD4-Positive T-LymphocytesCell DifferentiationCell MovementDown-RegulationEpitopes, T-LymphocyteFucosyltransferasesGangliosidesHistocompatibility Antigens Class IIHypersensitivity, DelayedInterleukin-12Interleukin-4InterphaseLewis Blood Group AntigensLymph NodesLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, TransgenicPeptide FragmentsRNA, MessengerSialyl Lewis X AntigenSialyltransferasesTh1 CellsTh2 CellsUp-Regulation
1998
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides
Chervonsky A, Medzhitov R, Denzin L, Barlow A, Rudensky A, Janeway C. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10094-10099. PMID: 9707606, PMCID: PMC21467, DOI: 10.1073/pnas.95.17.10094.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAntigens, Differentiation, B-LymphocyteB-LymphocytesCarrier ProteinsCell MembraneDimerizationHistocompatibility Antigens Class IIMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMolecular Sequence DataProtein BindingProtein ConformationT-Lymphocytes
1996
The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands
Sant'Angelo D, Waterbury G, Preston-Hurlburt P, Yoon S, Medzhitov R, Hong S, Janeway C. The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands. Immunity 1996, 4: 367-376. PMID: 8612131, DOI: 10.1016/s1074-7613(00)80250-2.Peer-Reviewed Original Research