2023
Modes of type 2 immune response initiation
Kopp E, Agaronyan K, Licona-Limón I, Nish S, Medzhitov R. Modes of type 2 immune response initiation. Immunity 2023, 56: 687-694. PMID: 37044059, DOI: 10.1016/j.immuni.2023.03.015.Peer-Reviewed Original Research
2003
Toll-like receptors and their role in experimental models of microbial infection
Qureshi S, Medzhitov R. Toll-like receptors and their role in experimental models of microbial infection. Genes & Immunity 2003, 4: 87-94. PMID: 12618855, DOI: 10.1038/sj.gene.6363937.Peer-Reviewed Original ResearchConceptsImmune systemHost defenseToll-like receptor (TLR) familyExperimental modelTLR-deficient miceMicrobial infectionsAdaptive immune responsesToll-like receptorsEffective host defenseLimited human studiesInnate immune systemAdaptive immune systemPrompt recognitionImmune responseHuman studiesInnate immunityInfectious threatsInfectionReceptor familyAntimicrobial effectorsContainment measuresPathogen recognitionConstant surveillancePathogensActivation
2002
Toll-Like Receptors and Their Ligands
Barton G, Medzhitov R. Toll-Like Receptors and Their Ligands. Current Topics In Microbiology And Immunology 2002, 270: 81-92. PMID: 12467245, DOI: 10.1007/978-3-642-59430-4_5.Peer-Reviewed Original Research
2000
Large-Scale Culture and Selective Maturation of Human Langerhans Cells from Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Progenitors
Gatti E, Velleca M, Biedermann B, Ma W, Unternaehrer J, Ebersold M, Medzhitov R, Pober J, Mellman I. Large-Scale Culture and Selective Maturation of Human Langerhans Cells from Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Progenitors. The Journal Of Immunology 2000, 164: 3600-3607. PMID: 10725716, DOI: 10.4049/jimmunol.164.7.3600.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CD1Antigens, CD34Antigens, Differentiation, T-LymphocyteAntigens, NeoplasmCD40 LigandCell CountCell Culture TechniquesCell DifferentiationDendritic CellsGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell TransplantationHumansImmunophenotypingLangerhans CellsLeukapheresisLigandsLipopolysaccharidesMembrane GlycoproteinsStem CellsTumor Necrosis Factor-alphaConceptsDendritic cellsLangerhans cellsT cell stimulationG-CSF-mobilized patientsManipulation of DCsImmature dendritic cellsIL-12 productionPrimary immune responseHuman Langerhans cellsCell stimulationDifferent proinflammatory stimuliToll family receptorsDC preparationsMaturation stimuliTNF-alphaCD40 ligandMHC productsImmune responseBirbeck granulesProinflammatory stimuliCytokine removalFamily receptorsAg processingDC typesHomogenous population
1998
Innate immune recognition and control of adaptive immune responses
Medzhitov R, Janeway C. Innate immune recognition and control of adaptive immune responses. Seminars In Immunology 1998, 10: 351-353. PMID: 9799709, DOI: 10.1006/smim.1998.0136.Peer-Reviewed Original ResearchMyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProtein
1997
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov R, Preston-Hurlburt P, Janeway C. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388: 394-397. PMID: 9237759, DOI: 10.1038/41131.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsB7-1 AntigenCell LineCloning, MolecularDrosophilaDrosophila ProteinsHumansImmunityInsect ProteinsInterleukinsJurkat CellsMembrane GlycoproteinsMembrane ProteinsMiceMolecular Sequence DataMutationNF-kappa BReceptors, Cell SurfaceReceptors, ImmunologicRecombinant Fusion ProteinsSequence Homology, Amino AcidSignal TransductionT-LymphocytesToll-Like ReceptorsTransfectionConceptsDrosophila Toll proteinToll proteinCytoplasmic domainDrosophila TollHuman homologueLeucine-rich repeat domainNF-κB-controlled genesHuman cell linesRepeat domainActive mutantExtracellular domainNF-κBImmune responseInnate immune responseCo-stimulatory molecules B7.1Adaptive immune systemComponents of immunityInflammatory cytokines IL-1ProteinCell linesCo-stimulatory moleculesAntigen-presenting cellsAdaptive immune responsesNaive T cellsHomologuesInnate immunity: impact on the adaptive immune response
Medzhitov R, Janeway C. Innate immunity: impact on the adaptive immune response. Current Opinion In Immunology 1997, 9: 4-9. PMID: 9039775, DOI: 10.1016/s0952-7915(97)80152-5.Peer-Reviewed Original ResearchMeSH KeywordsImmunity, Innate
1996
Immunological tolerance: Danger – pathogen on the premises!
Janeway C, Goodnow C, Medzhitov R. Immunological tolerance: Danger – pathogen on the premises! Current Biology 1996, 6: 519-522. PMID: 8805259, DOI: 10.1016/s0960-9822(02)00531-6.Peer-Reviewed Original ResearchThe Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands
Sant'Angelo D, Waterbury G, Preston-Hurlburt P, Yoon S, Medzhitov R, Hong S, Janeway C. The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands. Immunity 1996, 4: 367-376. PMID: 8612131, DOI: 10.1016/s1074-7613(00)80250-2.Peer-Reviewed Original Research