2002
Deoxyribozymes: new activities and new applications
Emilsson G, Breaker R. Deoxyribozymes: new activities and new applications. Cellular And Molecular Life Sciences 2002, 59: 596-607. PMID: 12022469, PMCID: PMC11337523, DOI: 10.1007/s00018-002-8452-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBiotechnologyDNADNA, CatalyticGenomeKineticsMetalsModels, GeneticMolecular Sequence DataRNA
2001
Characterization of a DNA-Cleaving deoxyribozyme
Carmi N, Breaker R. Characterization of a DNA-Cleaving deoxyribozyme. Bioorganic & Medicinal Chemistry 2001, 9: 2589-2600. PMID: 11557347, DOI: 10.1016/s0968-0896(01)00035-9.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCatalysisCopperDeoxyadenosinesDeoxyribonucleotidesDNADNA, CatalyticDNA, Single-StrandedElectrophoresis, Gel, Two-DimensionalModels, MolecularMolecular StructureNucleic Acid ConformationOxidation-ReductionSequence Analysis, DNAStructure-Activity RelationshipSubstrate SpecificityIn Vitro Selection of Kinase and Ligase Deoxyribozymes
Li Y, Breaker R. In Vitro Selection of Kinase and Ligase Deoxyribozymes. Methods 2001, 23: 179-190. PMID: 11181037, DOI: 10.1006/meth.2000.1119.Peer-Reviewed Original ResearchConceptsDNA ligationModern living systemsDNA kinaseEnzymatic functionRandom sequence populationVitro SelectionProtein enzymesConstruction of DNADNA constructsDNA phosphorylationDNADeoxyribozymesKinaseLiving systemsFundamental roleChemical reactionsAdenylationFundamental questionsBiocatalysisPhosphorylationEnzymeBiotechnologySelection strategyDiscoveryDetailed overview
2000
Tech.Sight. Molecular biology. Making catalytic DNAs.
Breaker R. Tech.Sight. Molecular biology. Making catalytic DNAs. Science 2000, 290: 2095-6. PMID: 11187837, DOI: 10.1126/science.290.5499.2095.Peer-Reviewed Original ResearchCapping DNA with DNA †
Li Y, Liu Y, Breaker R. Capping DNA with DNA †. Biochemistry 2000, 39: 3106-3114. PMID: 10715132, DOI: 10.1021/bi992710r.Peer-Reviewed Original Research
1999
In vitro selection of deoxyribozymes with DNA capping activity.
Li Y, Liu Y, Breaker R. In vitro selection of deoxyribozymes with DNA capping activity. Nucleic Acids Symposium Series 1999, 42: 237-8. PMID: 10780467, DOI: 10.1093/nass/42.1.237.Peer-Reviewed Original ResearchDeoxyribozymes: New players in the ancient game of biocatalysis
Li Y, Breaker R. Deoxyribozymes: New players in the ancient game of biocatalysis. Current Opinion In Structural Biology 1999, 9: 315-323. PMID: 10361095, DOI: 10.1016/s0959-440x(99)80042-6.Peer-Reviewed Original ResearchConceptsSubstrate recognitionGenetic informationIdeal storage systemBiological catalysisRNA counterpartsInert characterChemical reactionsDNANovel chemicalRate enhancementSubstantial untapped potentialNew playersArtificial DNAHelical structurePolynucleotide chainSurprising varietyDeoxyribozymesRecent studiesStructure formationProteinCatalysisBiocatalysisStorage systemReactionChemicalsCatalytic DNA: in training and seeking employment
Breaker R. Catalytic DNA: in training and seeking employment. Nature Biotechnology 1999, 17: 422-423. PMID: 10331790, DOI: 10.1038/8588.Peer-Reviewed Original Research
1995
A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity
Breaker R, Joyce G. A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity. Cell Chemical Biology 1995, 2: 655-660. PMID: 9383471, DOI: 10.1016/1074-5521(95)90028-4.Peer-Reviewed Original Research