2018
Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells
Guo J, Hu H, Gorecka J, Bai H, He H, Assi R, Isaji T, Wang T, Setia O, Lopes L, Gu Y, Dardik A. Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells. American Journal Of Physiology - Cell Physiology 2018, 315: c885-c896. PMID: 30404559, PMCID: PMC6336941, DOI: 10.1152/ajpcell.00120.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBone Marrow CellsCell ProliferationCell SurvivalDiabetes Mellitus, ExperimentalGene Expression Regulation, DevelopmentalHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMiceNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor AWound HealingConceptsBone marrow-derived mesenchymal stem cellsBiomimetic collagen scaffoldStem cellsDiabetic wound healingMesenchymal stem cellsHuman diabeticsWound healingMouse modelMarrow-derived mesenchymal stem cellsSimilar extentBone marrow-derived cellsNotch signalingHuman diabetic woundsDiabetic C57BL/6 miceAdipose-derived mesenchymal stem cellsCell survivalMarrow-derived cellsEndothelial cell densityDiabetic mouse modelNumber of macrophagesNude mouse modelTissue-derived stem cellsCD31-positive cellsCellular proliferationSmooth muscle cells
2016
Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers
Assi R, Foster TR, He H, Stamati K, Bai H, Huang Y, Hyder F, Rothman D, Shu C, Homer-Vanniasinkam S, Cheema U, Dardik A. Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers. Regenerative Medicine 2016, 11: 245-260. PMID: 26986810, PMCID: PMC4976993, DOI: 10.2217/rme-2015-0045.Peer-Reviewed Original Research
2014
PDE‐5 inhibition improves skin flap viability in rats that are exposed to nicotine
Shah A, Pfaff MJ, Assi R, Wu W, Steinbacher DM. PDE‐5 inhibition improves skin flap viability in rats that are exposed to nicotine. Microsurgery 2014, 34: 390-397. PMID: 24610727, DOI: 10.1002/micr.22237.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFluorescein AngiographyIschemiaMaleNecrosisNicotineNicotinic AgonistsPhosphodiesterase 5 InhibitorsPiperazinesPurinesRats, WistarSildenafil CitrateSkinSulfonamidesSurgical FlapsVascular Endothelial Growth Factor AConceptsPDE-5 inhibitionSkin flap necrosisFlap necrosisNicotine SCSkin flapsPostoperative day 1Skin flap survivalPhosphodiesterase-5 inhibitionSildenafil-treated groupSkin flap viabilityDose-dependent reductionDays of treatmentWestern blot analysisDaily groupMcFarlane flapsFlap survivalFluorescence angiographyBlood flowGroup 2Group 1Blinded observersDay 1Flap viabilityDay 7Group 3