2000
Persistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion
McNulty P, Jagasia D, Cline G, Ng C, Whiting J, Garg P, Shulman G, Soufer R. Persistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion. Circulation 2000, 101: 917-922. PMID: 10694532, DOI: 10.1161/01.cir.101.8.917.Peer-Reviewed Original ResearchConceptsCoronary occlusionGlucose metabolismPostischemic stunningAnterolateral left ventricleHeart glucose metabolismCoronary artery occlusionRegional glucose metabolismMyocardial glucose metabolismRegional myocardial ischemiaRegional mechanical functionRapid reperfusionReversible coronary occlusionArtery occlusionMyocardial ischemiaIntact ratsPreferential shuntingBlood flowReperfusionTracer uptakeLeft ventricleGlycogen depletionMetabolic signaturesOcclusionPersistent changesSustained changesPET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.
van Dyck CH, Tan PZ, Baldwin RM, Amici LA, Garg PK, Ng CK, Soufer R, Charney DS, Innis RB. PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin. Journal Of Nuclear Medicine 2000, 41: 234-41. PMID: 10688105.Peer-Reviewed Original ResearchConceptsConstant infusion paradigmInfusion paradigmFrontal cortexAnterior cingulateVenous blood samplingPathophysiology of schizophreniaLipophilic radiometabolitesIntravenous administrationInfusion periodHealthy volunteersPET acquisitionReceptor densityBlood samplingTime-activity curvesConstant infusionLinear regression analysisH onwardMetabolite concentrationsBrain activityRegression analysisCingulateCortexHuman brainReceptorsPET quantification
1999
Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects
Bremner J, Baldwin R, Horti A, Staib L, Ng C, Tan P, Zea-Ponce Y, Zoghbi S, Seibyl J, Soufer R, Charney D, Innis R. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Research 1999, 91: 79-91. PMID: 10515463, DOI: 10.1016/s0925-4927(99)00015-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBenzodiazepine receptorsArterial blood samplesBenzodiazepine receptor bindingHealthy human subjectsHuman subjectsNeuroreceptor bindingSingle photon emissionSingle bolusOccipital cortexBlood samplesTemporal cortexEmission tomographyBrain compartmentsDynamic positron emission tomographyReceptor bindingSPECTSame human subjectsPhoton emissionCortexHuman brainRadioligandPreliminary findingsBrainReceptors
1998
Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake.
Ng C, Soufer R, McNulty P. Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake. Journal Of Nuclear Medicine 1998, 39: 379-83. PMID: 9529278.Peer-Reviewed Original ResearchConceptsCoronary sinus blood samplesIschemic heart diseasePrevious myocardial infarctionCoronary sinus catheterizationEffect of insulinLeft anteriorMale patientsMyocardial infarctionHeart diseaseFDG injectionVascular bedBlood samplesAwake statePatientsGlucose uptakeMyocardial kineticsFDGCatheterizationInfarctionDiabetesBolusAnteriorInsulinDisease
1995
Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia.
Ng C, Sinusas A, Zaret B, Soufer R. Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia. Circulation 1995, 92: 1261-8. PMID: 7648674, DOI: 10.1161/01.cir.92.5.1261.Peer-Reviewed Original Research
1992
Long-term outcome in patients with congestive heart failure and intact systolic left ventricular performance
Setaro J, Soufer R, Remetz M, Perlmutter R, Zaret B. Long-term outcome in patients with congestive heart failure and intact systolic left ventricular performance. The American Journal Of Cardiology 1992, 69: 1212-1216. PMID: 1575193, DOI: 10.1016/0002-9149(92)90938-u.Peer-Reviewed Original ResearchConceptsCongestive heart failureLV systolic functionLV ejection fractionLong-term outcomesThird heart soundCardiovascular eventsCardiovascular mortalitySystolic functionEjection fractionHeart failurePulmonary edemaAverage LV ejection fractionRecurrent congestive heart failureNormal LV systolic functionLeft ventricular systolic performanceSame favorable prognosisLV diastolic dysfunctionAcute pulmonary edemaFuture cardiovascular eventsHypertensive heart diseaseVentricular systolic performanceCoronary artery diseaseHeart soundNoncardiovascular mortalityCardiovascular morbidity
1991
Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest
Kayden D, Sigal S, Soufer R, Mattera J, Zaret B, Wackers F. Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. Journal Of The American College Of Cardiology 1991, 18: 1480-1486. PMID: 1939949, DOI: 10.1016/0735-1097(91)90678-3.Peer-Reviewed Original ResearchConceptsInjection of thalliumRedistribution imagesDefect reversibilityThallium-201 reinjectionThallium-201 defectsLate redistribution imagingPoor quality studiesDiagnostic informationClinical variablesRedistribution imagingThallium defectsThallium imagesMyocardial viabilityReversible defectsStress imagingThallium-201PatientsBetter diagnostic informationStress testingExercisePresent studyQuality studiesInjectionLate redistributionReinjection