2024
International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients
Tangel V, Hoeks S, Stolker R, Brown S, Pryor K, de Graaff J, Committee M, Pace N, Domino K, Muehlschlegel J, Kheterpal S, Vaughan M, Mathis M, Jiang S, Obembe S, Freundlich R, Schonberger R, Kim D. International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients. British Journal Of Anaesthesia 2024, 133: 1222-1233. PMID: 39477712, DOI: 10.1016/j.bja.2024.09.003.Peer-Reviewed Original ResearchIncidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients.
Ramachandran R, Behera A, Hussain Z, Peck J, Ananthakrishanan A, Mathur P, Banner-Goodspeed V, Muehlschlegel J, Pittet J, Bardia A, Schonberger R, Marcantonio E, Kveraga K, Subramaniam B. Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients. Anesthesia & Analgesia 2024 PMID: 39446661, DOI: 10.1213/ane.0000000000007209.Peer-Reviewed Original ResearchCerebral desaturationAortic cross-clampingCardiac surgeryPost-CPBBurst suppressionCross-clampingRemoval of aortic cross-clampCerebral oximetryAssociated with postoperative deliriumPhase of cardiac surgeryCardiac surgery patientsElectroencephalographic burst suppressionConfidence intervalsIntraoperative burst suppressionPostoperative cognitive functionPre-CPBPrecardiopulmonary bypassSurgery patientsEntire surgeryEEG monitoringPostoperative deliriumTargeted interventionsOdds ratioSurgerySurgical phaseAssociation of Medicare eligibility with access to cardiac surgical care by patients identifying as other than non-Hispanic White: a regression discontinuity analysis
Arndt M, Lin H, Strand E, Fisher C, Schonberger R. Association of Medicare eligibility with access to cardiac surgical care by patients identifying as other than non-Hispanic White: a regression discontinuity analysis. British Journal Of Anaesthesia 2024 PMID: 39277456, DOI: 10.1016/j.bja.2024.07.031.Peer-Reviewed Original ResearchAssociation between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study
Douville N, Smolkin M, Naik B, Mathis M, Colquhoun D, Kheterpal S, Collins S, Martin L, Popescu W, Pace N, Blank R, Committee M, Aziz M, Blasberg J, Chang A, Freundlich R, O’Reilly-Shah V, Schonberger R. Association between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study. British Journal Of Anaesthesia 2024, 133: 1073-1084. PMID: 39266439, DOI: 10.1016/j.bja.2024.08.005.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsOne-lung ventilationAssociated with postoperative pulmonary complicationsInspired oxygen fractionPulmonary complicationsThoracic surgeryLogistic regression modelsDevelopment of postoperative pulmonary complicationsIntraoperative inspired oxygen fractionDuration of one-lung ventilationReduce postoperative pulmonary complicationsMulticentre retrospective cohort studyComposite of postoperative pulmonary complicationsUS medical centresLung resection surgeryRetrospective multicentre studyThoracic surgical proceduresArea under the curveRetrospective cohort studyOxygen fractionExposure of interestResection surgeryMulticentre studyUnivariate analysisSurgical proceduresOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice.
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2024 PMID: 39167548, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDoseIdentifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis.
Lele A, Vail E, O'Reilly-Shah V, DeGraw X, Domino K, Walters A, Fong C, Gomez C, Naik B, Mori M, Schonberger R, Deshpande R, Souter M, Mathis M. Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis. Anesthesia & Analgesia 2024 PMID: 39167559, DOI: 10.1213/ane.0000000000007001.Peer-Reviewed Original ResearchIntraclass correlation coefficientMulticenter Perioperative Outcomes GroupOrgan procurement organization regionBrain-dead organ donorsNon-Hispanic whitesPoisson regression analysisOrgan procurement organizationsIntraoperative eventsUS hospitalsYears of ageMedication useIncidence of hypotensionOrgan donorsManagement of brain-dead donorsPrimary outcomeManagement of brain-dead organ donorsMixed-effects Poisson regression analysisIntravenous heparinVasoactive medicationsBrain-dead donorsMulticenter cohortIntraoperative managementTransplant outcomesCase volumeMm HgPreoperative Blood Pressures and the Physician Anesthesiologist
Schonberger R. Preoperative Blood Pressures and the Physician Anesthesiologist. Anesthesiology 2024, 141: 208-210. PMID: 38980164, PMCID: PMC11239125, DOI: 10.1097/aln.0000000000005101.Peer-Reviewed Original ResearchAnesthesia Techniques for Vitreoretinal Surgery in the United States: A Report from the Multicenter Perioperative Outcomes Group Research Consortium
Chauhan M, SOLIMAN M, Pace N, Mathis M, Schonberger R, Sallam A, Group M. Anesthesia Techniques for Vitreoretinal Surgery in the United States: A Report from the Multicenter Perioperative Outcomes Group Research Consortium. American Journal Of Ophthalmology 2024, 267: 30-40. PMID: 38871268, DOI: 10.1016/j.ajo.2024.06.010.Peer-Reviewed Original ResearchMonitored anesthesia careVR surgeryMulticenter Perioperative Outcomes GroupGeneral anesthesiaAmerican Society of Anesthesiologists (ASAHistory of drug abuseChronic pulmonary diseaseType of anesthesiaMonitored anesthesia care casesAlcohol abuse disordersMultivariate mixed-effects modelRandom-effects modelRetinal detachmentSB surgeryVitreoretinal surgeryYounger patientsAnesthesia useSurgery casesOutcome groupAnesthesia techniquesPrimary outcomeSurgeryLiver diseaseSecondary outcomesPulmonary diseaseSame-Day Primary Care Referral Versus Usual Care for Patients With Elevated Blood Pressures Seen in a Preoperative Clinic
Butler S, Holt N, Dai F, Quick C, Kravetz J, Perrino A, Schonberger R. Same-Day Primary Care Referral Versus Usual Care for Patients With Elevated Blood Pressures Seen in a Preoperative Clinic. Cureus 2024, 16: e58401. PMID: 38756290, PMCID: PMC11098054, DOI: 10.7759/cureus.58401.Peer-Reviewed Original ResearchPrimary care referralsPrimary care groupsCare referralUsual careCare groupPreoperative clinicQuality improvementCare coordination effortsLong-term health outcomesPrimary care visitsPrimary care appointmentsCohort of US veteransMonths post-interventionSame-day referralElectronic health recordsBlood pressureSurgical care episodesHypertension treatmentProspective QI projectPreoperative evaluation clinicImprove BP controlQI projectCare appointmentsPreoperative clinic visitPrimary careImproving Anesthesia Start Time Documentation Through a Departmental Education Initiative at Yale New Haven Hospital, New Haven, United States
Warren M, Mehta S, Glowka L, Goncalves O, Gutman E, Schonberger R. Improving Anesthesia Start Time Documentation Through a Departmental Education Initiative at Yale New Haven Hospital, New Haven, United States. Cureus 2024, 16: e54351. PMID: 38500895, PMCID: PMC10945460, DOI: 10.7759/cureus.54351.Peer-Reviewed Original ResearchYale-New Haven HospitalEducational emailCenters for Medicare & Medicaid ServicesEducational initiativesResults Baseline dataQuality improvement studyQuality improvement initiativesQuality improvement effortsNew HavenAnesthesia startUnited StatesImprovement initiativesMedicaid ServicesAnesthetic servicesImprovement studyImprovement effortsIn-room timeDocumentation accuracyAmerican Society of AnesthesiologistsTime documentationPatient factorsBaseline dataPreoperative holding areaNew Haven HospitalAnesthesia practitioners
2023
Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study
Aziz M, Schenning K, Koike S, O’Glasser A, O’Reilly-Shah V, Sera V, Mathis M, Naik B, Taicher B, Colquhoun D, Freundlich R, Schonberger R, Domino K, Chen L, Pace N. Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study. Anesthesiology 2023, 140: 195-206. PMID: 37844271, DOI: 10.1097/aln.0000000000004809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPulmonary complicationsKidney injuryIncreased riskPerioperative mortalityExposed patientsCOVID-19 infectionIncreased 30-day mortality riskElective surgeryIncreased risk of acute kidney injuryIncreased risk of pulmonary complicationsRisk of acute kidney injuryMortality riskPositive testRisk of pulmonary complicationsRisk of perioperative mortalityRetrospective observational cohort studyThirty-day mortalityCOVID-19-recovered patientsCohort of patientsExposure to COVID-19 infectionIncreased risk of mortalityAssociated with increased mortality riskObservational cohort studyElective inpatient surgeryHypoxemia in School-age Children Undergoing One-lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group
Templeton T, Krol B, Miller S, Lee L, Mathis M, Vishneski S, Chatterjee D, Gupta R, Shroeder R, Saha A, Schonberger R. Hypoxemia in School-age Children Undergoing One-lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group. Anesthesiology 2023, 140: 25-37. PMID: 37738432, DOI: 10.1097/aln.0000000000004781.Peer-Reviewed Original ResearchConceptsIncreased risk of hypoxemiaOne-lung ventilationRisk of hypoxemiaRight-sided casesIncreased riskSevere hypoxemiaDuration of one-lung ventilationVideo-assisted thoracoscopic surgeryRoom air oxygen saturationLow tidal volume ventilationRisk factorsOxygen saturationMulticenter Perioperative Outcomes Group databasePrevalence of hypoxemiaAssociated with hypoxemiaAssociated with increased riskTidal volume ventilationRetrospective cohort studySelection operator regression analysisChildren 4Nonmodifiable risk factorsMultivariate least absolute shrinkageSchool-aged childrenThoracoscopic surgeryThoracic surgeryPatient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis
Mathis M, Janda A, Kheterpal S, Schonberger R, Pagani F, Engoren M, Mentz G, Shook D, Muehlschlegel J, Cassidy R, Clark D, Colquhoun D, Freundlich R, Jewell E. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023, 139: 122-141. PMID: 37094103, PMCID: PMC10524016, DOI: 10.1097/aln.0000000000004593.Peer-Reviewed Original ResearchConceptsInotrope useCardiac surgeryHome medicationsAdjusted median odds ratioPulmonary circulation disordersAdult cardiac surgeryMechanical circulatory supportMedian odds ratioMedical school affiliationHome inotropesInotrope infusionInotrope therapyInotropic therapyCardiopulmonary bypassHeart failureMulticenter cohortPrimary outcomeCirculatory supportBlack raceCirculation disordersOdds ratioCommunity hospitalObservational studySame patientPatientsAssociation of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections
Bardia A, Michel G, Farela A, Fisher C, Mori M, Huttler J, Lang A, Geirsson A, Schonberger R. Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections. Journal Of Thoracic And Cardiovascular Surgery 2023, 167: 2170-2176.e5. PMID: 37075942, PMCID: PMC10579454, DOI: 10.1016/j.jtcvs.2023.03.031.Peer-Reviewed Original ResearchWeight-adjusted dosingPostoperative infectionAntibiotic guidelinesIncidence of nonadherenceCoronary artery bypassTertiary care hospitalAssociation of adherenceCohort of patientsRetrospective observational studyPost-operative infectionIntraoperative redosingValvular surgeryAntibiotic timingArtery bypassCoronary revascularizationPostoperative complicationsPostoperative sepsisAdult patientsFirst doseAntibiotic choiceCardiac surgeryCardiopulmonary bypassCare hospitalDose adjustmentPrimary outcomeSystemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty
Sharma A, Dai F, Tseng L, Effraim P, Zhou B, Schonberger R, Li J. Systemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty. Journal Of Pain Research 2023, 16: 553-561. PMID: 36846205, PMCID: PMC9946012, DOI: 10.2147/jpr.s395336.Peer-Reviewed Original ResearchWhite blood cell countTotal hip arthroplastyBlood cell countSerum glucosePAI groupSerum potassiumPOD 2Hip arthroplastySystemic effectsCell countTertiary academic medical centerPrimary total hip arthroplastyRetrospective cohort studyPostoperative day 1Immediate postoperative periodLocal anesthetic injectionPeripheral nerve blocksAcademic medical centerPotential systemic effectsElectronic health recordsPreoperative baselineCohort studyPostoperative periodSecondary outcomesPOD 3Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis
Carr Z, Yan L, Yanez N, Schonberger R, Bohorquez M, He Z, Li F, Hines R, Treggiari M. Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis. Medical Research Archives 2023, 11: 10.18103/mra.v11i10.4606. PMID: 38037571, PMCID: PMC10688569, DOI: 10.18103/mra.v11i10.4606.Peer-Reviewed Original ResearchMajor adverse cardiac eventsSystemic sclerosisLength of stayPerioperative complicationsSSc patientsComparative cohort analysisSSc cohortPerioperative outcomesControl cohortCohort analysisCormack-Lehane grade 3Limited cervical rangeAdverse cardiac eventsRare autoimmune disorderComparative cohort studySurgical site infectionBetween-group differencesQuaternary care institutionMultiple organ systemsHigh rateAirway complicationsComposite infectionHospital complicationsCardiac eventsCohort study
2022
Geospatial analysis of patients’ social determinants of health for health systems science and disparity research
Pearson J, Jacobson C, Ugochukwu N, Asare E, Kan K, Pace N, Han J, Wan N, Schonberger R, Andreae M. Geospatial analysis of patients’ social determinants of health for health systems science and disparity research. International Anesthesiology Clinics 2022, 61: 49-62. PMID: 36480649, PMCID: PMC10107426, DOI: 10.1097/aia.0000000000000389.Peer-Reviewed Original ResearchEfficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial
Bardia A, Treggiari M, Dai F, Johnson C, Singh M, Kunze K, Tickoo M, Tantawy H, Giersson A, Darr U, Schonberger R. Efficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial. Critical Care Explorations 2022, 4: e0821. PMID: 36601562, PMCID: PMC9788969, DOI: 10.1097/cce.0000000000000821.Peer-Reviewed Original ResearchAortic valve replacementCardiac surgeryNeuromuscular blockadeCombined Aortic Valve ReplacementElective aortic valve replacementEfficacy of sugammadexStudy drug administrationCoronary artery bypassPlacebo-controlled trialPrimary study endpointResidual neuromuscular blockadeUse of sugammadexArtery bypassPlacebo groupSugammadex groupBaseline characteristicsValve replacementAnesthetic medicationsStudy endpointMechanical ventilationModifiable factorsCardiothoracic ICUICU settingNMB reversalPatientsOxygen administration during surgery and postoperative organ injury: observational cohort study
McIlroy D, Shotwell M, Lopez M, Vaughn M, Olsen J, Hennessy C, Wanderer J, Semler M, Rice T, Kheterpal S, Billings F, Group M, Cuff G, Freundlich R, Kurz A, Naik B, Mathis M, Schonberger R. Oxygen administration during surgery and postoperative organ injury: observational cohort study. The BMJ 2022, 379: e070941. PMID: 36450405, PMCID: PMC9710248, DOI: 10.1136/bmj-2022-070941.Peer-Reviewed Original ResearchConceptsAcute kidney injuryObservational cohort studyLung injuryKidney injuryMyocardial injuryOxygen administrationGreater oddsCohort studyMedian age 59 yearsHospital discharge diagnosis codesGlobal Outcomes criteriaAge 59 yearsHours of surgeryDischarge diagnosis codesPotential confounding variablesHemoglobin oxygen saturationPostoperative kidneyPrimary endpointAdult patientsMedian durationOrgan injurySerum troponinEndotracheal intubationGeneral anesthesiaKidney diseaseAssociation between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study
Colquhoun D, Vaughn M, Bash L, Janda A, Shah N, Ghaferi A, Sjoding M, Mentz G, Kheterpal S, Committee M, Craft R, Domino K, Freundlich R, Mathis M, McCormick P, Naik B, Ruiz J, Schonberger R, Schroeder R, Stewart A, Taicher B, Tingle S, Togioka B, Urman R, Vachhani S. Association between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study. British Journal Of Anaesthesia 2022, 130: e148-e159. PMID: 35691703, PMCID: PMC9875908, DOI: 10.1016/j.bja.2022.04.023.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsPulmonary complicationsNon-emergency surgeryRespiratory failureCohort studyNeuromuscular blockReversal agentsAnesthesiologists physical status 3Primary composite outcomeCohort of patientsUse of sugammadexIntra-abdominal surgeryOccurrence of pneumoniaBody mass indexSource of morbidityNeuromuscular blocking agentsStatus 3Complication outcomesComposite outcomeMajor surgeryPrimary outcomeMass indexTracheal intubationGeneral anesthesiaMulticenter Perioperative Outcomes Group