2024
Bone erosions and joint damage caused by chikungunya virus: a systematic review
Amaral J, Taylor P, Schoen R. Bone erosions and joint damage caused by chikungunya virus: a systematic review. Revista Da Sociedade Brasileira De Medicina Tropical 2024, 57: e00404-2024. PMID: 38597523, PMCID: PMC11000508, DOI: 10.1590/0037-8682-0433-2023.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisJoint damageRheumatoid arthritisJoint painDisease-modifying antirheumatic drug therapyBone erosionProgression of radiographic joint damageDisease-modifying antirheumatic drugsSystematic reviewAntirheumatic drug therapyAcute febrile illnessPersistent joint painSimilar to rheumatoid arthritisRadiographic joint damageChikungunya virusYears post-infectionChronic joint damagePrevent joint damageDisease-modifying therapiesJoint structural damageRheumatoid arthritis treatmentAntirheumatic drugsProspective studyChikungunya infectionQuality of Life and Disability in Chikungunya Arthritis
Amaral J, Taylor P, Weinblatt M, Bandeira Í, Schoen R. Quality of Life and Disability in Chikungunya Arthritis. Current Rheumatology Reviews 2024, 20: 65-71. PMID: 37605393, DOI: 10.2174/1573397119666230726113647.Peer-Reviewed Original ResearchConceptsChikungunya arthritisVisual analog scaleSF-12Quality of lifeChikungunya feverVisual analog scale pain scoreShort Form Health SurveyHealth Assessment Questionnaire Disability IndexRetrospective cross-sectional studyVirus-infected patientsCKV patientsCross-sectional studyPublic health impactChikungunya fever patientsChikungunya virus infectionMCS-12PCS-12Assess disabilityOutbreak of chikungunya feverHealth SurveyDisability IndexPain scoresDAS28-ESRAnalog scaleMosquito vectors
2022
Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis. Travel Medicine And Infectious Disease 2022, 52: 102534. PMID: 36549417, DOI: 10.1016/j.tmaid.2022.102534.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisMesenchymal stem cellsJoint painChikungunya virusReactivation of dormant virusesMorphologically similar to fibroblastsChikungunya feverEpigenetic changesChronic joint painAcute febrile illnessChikungunya virus infectionSimilar to fibroblastsMaculopapular rashChikungunya arthritisDormant virusesFebrile illnessLatent infectionMultipotent cellsStem cellsHeterogeneous groupRheumatoid arthritisPathogenic hypothesisGroup of multipotent cellsPainPatients
2007
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis
Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. Journal Of Experimental Medicine 2007, 205: 133-141. PMID: 18166585, PMCID: PMC2234379, DOI: 10.1084/jem.20070962.Peer-Reviewed Original ResearchConceptsLyme arthritisMouse jointsB. burgdorferi antigensBurgdorferi-infected miceSevere arthritisSpirochete numbersArthritisHost responseLyme diseaseAffinity-purified antibodiesBorrelia burgdorferiChain reactionMiceOriginal phenotypeBasic membrane proteinMutant spirochetesGene expressionJointsInflammationPathogenesisAntigenDiseaseB. burgdorferi gene expression
2000
The Lyme disease vaccine: conception, development, and implementation.
Thanassi W, Schoen R. The Lyme disease vaccine: conception, development, and implementation. Annals Of Internal Medicine 2000, 132: 661-8. PMID: 10766685, DOI: 10.7326/0003-4819-132-8-200004180-00009.Peer-Reviewed Original Research