2024
Chikungunya Arthritis Treatment with Methotrexate and Dexamethasone: A Randomized, Double-blind, Placebo-controlled Trial
Amaral J, Lucena G, Schoen R. Chikungunya Arthritis Treatment with Methotrexate and Dexamethasone: A Randomized, Double-blind, Placebo-controlled Trial. Current Rheumatology Reviews 2024, 20: 337-346. PMID: 38173199, DOI: 10.2174/0115733971278715231208114037.Peer-Reviewed Original ResearchChronic chikungunya arthritisChikungunya arthritisDouble-blindJoint countPlacebo-controlled clinical trialPain visual analog scalePlacebo-controlled trialChikungunya feverPatient global assessmentVisual analog scaleAffected individualsSwollen joint countTender joint countChikungunya virus infectionDAS28-ESRDexamethasone groupSD ageAnalog scaleBiphasic diseaseTreatment responseClinical trialsAcute phaseDexamethasoneVirus infectionGlobal assessment
1985
Successful Parenteral Penicillin Therapy of Established Lyme Arthritis
Steere A, Green J, Schoen R, Taylor E, Hutchinson G, Rahn D, Malawista S. Successful Parenteral Penicillin Therapy of Established Lyme Arthritis. New England Journal Of Medicine 1985, 312: 869-874. PMID: 3883177, DOI: 10.1056/nejm198504043121401.Peer-Reviewed Original ResearchConceptsLyme arthritisComplete resolutionDouble-blind placebo-controlled trialAttacks of arthritisIntravenous penicillin GParenteral penicillin therapyPlacebo-controlled trialPenicillin-treated patientsErythema chronicum migransMean followPenicillin therapyParenteral therapyParenteral penicillinIntraarticular corticosteroidsJoint fluidArthritisPatientsLyme spirocheteFurther experienceTherapyPenicillin GOptimal courseDaysCorticosteroidsPlacebo