2024
Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Jha M, Wilkinson S, Krishnan K, Collins K, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew S, Anand A. Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression. JAMA Network Open 2024, 7: e2417786. PMID: 38916891, PMCID: PMC11200139, DOI: 10.1001/jamanetworkopen.2024.17786.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionQIDS-SR16 scoresElectroconvulsive therapy groupElectroconvulsive therapyQIDS-SR16Measure of premorbid intelligencePosttraumatic stress disorder diagnosisTrial of electroconvulsive therapyNonpsychotic depressive episodeImpaired memory recallAssociated with differential improvementStress disorder diagnosisIntravenous ketamineEnd-of-treatment visitInfusion of ketamineMADRS scorePremorbid intelligenceResistant depressionDepressive episodeMeasures mixed-effects modelsFalse discovery rate adjustmentDisorder diagnosisMemory recallSevere depressionDifferential improvement
2023
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
Anand A, Mathew S, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Collins K, Costi S, Iqbal S, Jha M, Krishnan K, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wilkinson S, Wolski K, Hu B. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. New England Journal Of Medicine 2023, 388: 2315-2325. PMID: 37224232, DOI: 10.1056/nejmoa2302399.Peer-Reviewed Original ResearchConceptsTreatment-resistant major depressionPatient-reported qualityElectroconvulsive therapyMajor depressionECT groupKetamine groupTreatment phaseMusculoskeletal adverse effectsSubanesthetic intravenous ketamineWeeks of treatmentInitial treatment phaseIntravenous ketamineSecondary outcomesPrimary outcomeNoninferiority marginTrial groupECT clinicsNoninferiority trialPatientsComparative effectivenessKetamineClinical sitesAdverse effectsDepressionThree times
2012
When Cardiac Patients Need ECT—Challenges for the Anesthesiologist
Kurup V, Ostroff R. When Cardiac Patients Need ECT—Challenges for the Anesthesiologist. International Anesthesiology Clinics 2012, 50: 128-140. PMID: 22481560, DOI: 10.1097/aia.0b013e31824ff57c.Peer-Reviewed Original Research
2005
Chronic Renal Failure, Hemodialysis, and Electroconvulsive Therapy
Williams S, Ostroff R. Chronic Renal Failure, Hemodialysis, and Electroconvulsive Therapy. Journal Of Ect 2005, 21: 41-42. PMID: 15791177, DOI: 10.1097/01.yct.0000156404.61098.5b.Peer-Reviewed Case Reports and Technical NotesConceptsChronic renal failureElectroconvulsive therapyRenal failureHamilton Depression Rating Scale scoresDepression Rating Scale scoresBilateral electroconvulsive therapyBipolar I depressionRating Scale scoresOral intakeAntidepressant regimensPsychotic depressionPatient populationSevere hypokinesiaScale scoreTherapyHemodialysisRobust responseDepressionRegimensHypokinesiaPatientsFailureIntake