1990
A multicenter clinical trial of oral ribavirin in HIV-infected patients with lymphadenopathy. The Ribavirin-LAS Collaborative Group.
Roberts R, Dickinson G, Heseltine P, Leedom J, Mansell P, Rodriguez S, Johnson K, Lubina J, Makuch R. A multicenter clinical trial of oral ribavirin in HIV-infected patients with lymphadenopathy. The Ribavirin-LAS Collaborative Group. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1990, 3: 884-92. PMID: 1974628.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdministration, OralAdolescentAdultCD4 AntigensCD4-Positive T-LymphocytesDose-Response Relationship, DrugDouble-Blind MethodEvaluation Studies as TopicHumansImmunoblastic LymphadenopathyLeukocyte CountMaleMiddle AgedMulticenter Studies as TopicRandomized Controlled Trials as TopicRibavirinRibonucleosidesConceptsOral ribavirinActive treatmentBaseline CD4 cell countMajor protocol violationsCD4 cell countPlacebo-controlled trialMulticenter clinical trialSignificant differencesPlacebo patientsPlacebo groupPlacebo treatmentStudy entryTreat analysisWashout periodDaily dosesClinical trialsKaposi's sarcomaProtocol violationsMedical CenterTreatment superiorityTreatment groupsPlaceboRibavirinPatientsOverall significant difference
1989
Survival in Children with Perinatally Acquired Human Immunodeficiency Virus Type 1 Infection
Scott G, Hutto C, Makuch R, Mastrucci M, O'Connor T, Mitchell C, Trapido E, Parks W. Survival in Children with Perinatally Acquired Human Immunodeficiency Virus Type 1 Infection. New England Journal Of Medicine 1989, 321: 1791-1796. PMID: 2594038, DOI: 10.1056/nejm198912283212604.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBacterial InfectionsBrain DiseasesChild, PreschoolFemaleFloridaHIV-1HumansInfantInfant, NewbornMalePneumonia, PneumocystisPregnancyPrognosisPulmonary FibrosisRecurrenceSurvival RateConceptsMedian survivalMedian ageHuman immunodeficiency virus type 1 (HIV-1) infectionHuman immunodeficiency virus type 1Virus type 1 infectionImmunodeficiency virus type 1Common first manifestationLymphoid interstitial pneumoniaIntravenous drug useProportional hazards analysisTime of diagnosisPneumocystis carinii pneumoniaHIV-1 infectionMedian survival timeType 1 infectionRecurrent bacterial infectionsJackson Memorial HospitalLong-term survivalYears of ageVirus type 1Candida esophagitisProgressive diseaseAntiviral treatmentBlood transfusionInterstitial pneumoniaGoodman and Kruskal's λ: A new look at an old measure of association
Makuch R, Rosenberg P, Scott G. Goodman and Kruskal's λ: A new look at an old measure of association. Statistics In Medicine 1989, 8: 619-631. PMID: 2727480, DOI: 10.1002/sim.4780080511.Peer-Reviewed Original ResearchAcquired Immunodeficiency SyndromeAdolescentAdultAnalysis of VarianceChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalePrognosisRegression Analysis
1988
Statistical Methods for the Analysis of HIV-1 Core Polypeptide Antigen Data in Clinical Studies
Makuch R, Parks W. Statistical Methods for the Analysis of HIV-1 Core Polypeptide Antigen Data in Clinical Studies. AIDS Research And Human Retroviruses 1988, 4: 305-316. PMID: 3061416, DOI: 10.1089/aid.1988.4.305.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS-Related ComplexCells, CulturedClinical Trials as TopicHIV AntigensHIV-1HumansLymphocytesModels, StatisticalProspective StudiesRandom AllocationZidovudineConceptsPlacebo-treated patientsInitiation of therapyPlacebo-controlled studyHIV-1 antigensDemonstrated clinical efficacyHIV-1 coreAntiretroviral effectClinical efficacyAIDS patientsAntiretroviral activityClinical studiesLymphocyte culturesVirus expressionSerum dataAntigen dataPatientsSurvival analysis methodsLaboratory dataAZTGroup differencesMost laboratory dataCulture dataStatistical methodsSignificant declineSerum