2024
Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRaceBicuspid Aortic Valve: Current Therapeutic Strategies
Usman Bin Mahmood S, Vallabhajosyula P, Milewski R. Bicuspid Aortic Valve: Current Therapeutic Strategies. Cardiology And Cardiovascular Medicine 2024, 1 DOI: 10.5772/intechopen.113315.Peer-Reviewed Original ResearchBicuspid aortic valveAortic valveTherapeutic strategiesValve-sparing root reimplantationBicuspid aortic valve patientsBAV syndromeSurgical therapeutic strategiesAortic valve replacementAortic valve patientsAortic valve stenosisAortic valve repairLong-term outcomesCurrent therapeutic strategiesBAV populationAorta replacementBentall procedureValve patientsValve replacementValve stenosisRoot reimplantationValve repairValvular pathologySurgical proceduresGeneral populationIndividualized approach
2023
Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study
Mangino J, Firstenberg M, Milewski R, Rhys-Williams W, Lees J, Dane A, Love W, Moreno J. Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study. Infection Control And Hospital Epidemiology 2023, 44: 1171-1173. PMID: 36951472, PMCID: PMC10369221, DOI: 10.1017/ice.2023.17.Peer-Reviewed Original Research
2022
Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly intervention
2021
CARDIAC STRUCTURAL CHANGES, END-ORGAN MORBIDITIES AND MORTALITY RELATE TO AORTIC STENOSIS IN A DEGREE-REPONSE RELATIONSHIP
Yousef S, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Geirsson A, Vallabhajosyula P. CARDIAC STRUCTURAL CHANGES, END-ORGAN MORBIDITIES AND MORTALITY RELATE TO AORTIC STENOSIS IN A DEGREE-REPONSE RELATIONSHIP. Journal Of The American College Of Cardiology 2021, 77: 1750. DOI: 10.1016/s0735-1097(21)03106-5.Peer-Reviewed Original Research
2018
Hypoxia and Complications of Oxygenation in Extracorporeal Membrane Oxygenation
Alexis-Ruiz A, Ghadimi K, Raiten J, Mackay E, Laudanski K, Cannon J, Ramakrishna H, Evans A, Augoustides J, Vallabhajosyula P, Milewski R, McDonald M, Patel P, Vernick W, Gutsche J. Hypoxia and Complications of Oxygenation in Extracorporeal Membrane Oxygenation. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 1375-1381. PMID: 30082128, DOI: 10.1053/j.jvca.2018.05.028.Peer-Reviewed Educational Materials
2017
Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation
Diamond J, Cantu E, Porteous M, Suzuki Y, Meyer K, Lederer D, Milewski R, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett J, Singh G, Costa J, Tobias J, Rodriguez H, Van Deerlin V, Olthoff K, Shaked A, Chang B, Christie J, Investigators T. Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal Of Transplantation 2017, 17: 1770-1777. PMID: 28117940, PMCID: PMC5489369, DOI: 10.1111/ajt.14209.Peer-Reviewed Original ResearchConceptsPrimary graft dysfunctionGraft dysfunctionLung transplantationPeripheral blood gene expressionFirst transplant yearImmune regulation genesInflammasome-related proteinsDays of transplantBlood of patientsAdaptive immunity genesBlood gene expressionAllograft reperfusionTransplant yearClinical trialsPGD developmentGrade 3T cellsTransplantGene expressionHypothesis-driven genesRNA expressionGene expression changesReperfusionAllograftsPatients
2016
The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction
Abbas A, Diamond J, Chehoud C, Chang B, Kotzin J, Young J, Imai I, Haas A, Cantu E, Lederer D, Meyer K, Milewski R, Olthoff K, Shaked A, Christie J, Bushman F, Collman R. The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction. American Journal Of Transplantation 2016, 17: 1313-1324. PMID: 27731934, PMCID: PMC5389935, DOI: 10.1111/ajt.14076.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesDNA, ViralFemaleFollow-Up StudiesGenome, ViralGraft RejectionGraft SurvivalHumansLung TransplantationMaleMetagenomicsMiddle AgedPerioperative CarePrimary Graft DysfunctionPrognosisProspective StudiesRespiratory SystemRisk FactorsTissue DonorsTorque teno virusConceptsPrimary graft dysfunctionTorque teno virusGraft dysfunctionDonor lungsTTV levelsGreater immune activationTTV DNA levelsStandard clinical assaysRespiratory tract bacteriaPGD casesQuantitative polymerase chain reactionEarly morbidityLung allograftsLung transplantationPGD statusTTV replicationBronchoalveolar lavageControl recipientsImmune activationPolymerase chain reactionHealthy controlsBrain deathRecipient pairsTissue injuryDonor organs
2014
004DISTAL AORTIC REINTERVENTION AFTER SURGERY FOR ACUTE TYPE A AORTIC DISSECTION: OPEN VERSUS ENDOVASCULAR REPAIR
Rylski B, Beyersdorf F, Desai N, Siepe M, Kari F, Vallabhajosyula P, Milewski R, Bavaria J. 004DISTAL AORTIC REINTERVENTION AFTER SURGERY FOR ACUTE TYPE A AORTIC DISSECTION: OPEN VERSUS ENDOVASCULAR REPAIR. Interdisciplinary CardioVascular And Thoracic Surgery 2014, 19: s2-s2. DOI: 10.1093/icvts/ivu276.4.Peer-Reviewed Original ResearchDistal aortic pathologyDistal reinterventionDissection repairEndovascular groupHospital mortalityAcute typeAortic pathologyAortic dissection type AOpen Versus Endovascular RepairOpen repair patientsAortic reinterventionEndovascular patientsLate reinterventionSpinal ischaemiaEndovascular reinterventionEndovascular repairRepair patientsAortic dissectionConsecutive patientsEndovascular approachSurgical repairTertiary centerMedian timeProximal repairEndovascular intervention
2013
137TRANSCATHETER AORTIC VALVE IMPLANTATION IN PATIENTS WITH ASCENDING AORTIC DILATATION: SAFETY OF THE PROCEDURE AND MID-TERM FOLLOW-UP OF 100 PATIENTS
Rylski B, Szeto W, Bavaria J, Walsh E, Anwaruddin S, Desai N, Herrmann H, Milewski R. 137TRANSCATHETER AORTIC VALVE IMPLANTATION IN PATIENTS WITH ASCENDING AORTIC DILATATION: SAFETY OF THE PROCEDURE AND MID-TERM FOLLOW-UP OF 100 PATIENTS. Interdisciplinary CardioVascular And Thoracic Surgery 2013, 17: s102-s103. DOI: 10.1093/icvts/ivt372.137.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationAortic valve implantationAortic dilatationAortic diameterValve implantationSafety of TAVIAdverse aortic eventsAscending Aortic DilatationFourth of patientsModerate aortic dilatationSevere aortic stenosisOne-year survivalAscending aortic diameterHospital mortalityAortic eventsAortic interventionIatrogenic dissectionAortic ruptureAortic stenosisHeart failureModerate dilatationInclusion criteriaPatientsDilatationAorta164GENDER-RELATED CHANGES IN AORTIC GEOMETRY THROUGHOUT LIFE
Rylski B, Desjardins B, Moser W, Bavaria J, Milewski R. 164GENDER-RELATED CHANGES IN AORTIC GEOMETRY THROUGHOUT LIFE. Interdisciplinary CardioVascular And Thoracic Surgery 2013, 17: s109-s109. DOI: 10.1093/icvts/ivt372.164.Peer-Reviewed Original ResearchAortic dissectionAortic diameterContrast-enhanced computed tomography scanSmaller aortic dimensionsTotal aortic volumeYoung male patientComputed tomography scanAortic geometryImpact of ageCurvature tortuosityMale patientsAortic dimensionsGender-related changesVascular diseaseAortic lengthTomography scanAortic volumeFemale genderWhole aortaNinth decadeNormal aortaWomenAnatomical segmentsAgeAortaGene Set Enrichment Analysis of Bronchial Alveolar Lavage Fluid Identifies Key Innate Immune Pathways in Primary Graft Dysfunction after Lung Transplantation
Cantu E, Lederer D, Meyer K, Milewski R, Suzuki Y, Shah R, Diamond J, Meyer N, Tobias J, Baldwin D, Van Deerlin V, Olthoff K, Shaked A, Christie J. Gene Set Enrichment Analysis of Bronchial Alveolar Lavage Fluid Identifies Key Innate Immune Pathways in Primary Graft Dysfunction after Lung Transplantation. The Journal Of Heart And Lung Transplantation 2013, 32: s41-s42. DOI: 10.1016/j.healun.2013.01.908.Peer-Reviewed Original ResearchGraft dysfunctionGene Set Enrichment AnalysisNontypeable Hemophilus influenzaeLung transplant patientsPrimary graft dysfunctionAffymetrix Human Gene 1.0 ST arraysHours of reperfusionToll-like receptorsIL-1 receptorHuman Gene 1.0 ST arraysEnrichment analysisOrgan transplantation studiesCase-control designLung transplantationTransplant patientsLung injuryRecipient diagnosisTLR-9Lavage fluidClinical trialsDonor ageTLR pathwayHemophilus influenzaeImmune pathwaysMRNA expression
2006
Serum Response Factor Is Regionally Expressed in Ischemic Cardiomyopathy
Milewski R, Hamamoto H, Kanemoto S, Immanuel C, Plappert T, Parmacek M, Gorman J, Gorman R. Serum Response Factor Is Regionally Expressed in Ischemic Cardiomyopathy. Journal Of Cardiac Failure 2006, 12: s44. DOI: 10.1016/j.cardfail.2006.06.154.Peer-Reviewed Original Research