ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility
Pathak GA, Wendt FR, Goswami A, Koller D, De Angelis F, Initiative C, Polimanti R. ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility. Frontiers In Genetics 2021, 12: 698033. PMID: 34512723, PMCID: PMC8429844, DOI: 10.3389/fgene.2021.698033.Peer-Reviewed Original ResearchGenome-wide association studiesGenetic variationFunctional characterizationCOVID-19 susceptibilityHuman genetic variationSilico functional characterizationDrug-gene interaction databaseTranscriptomic regulationGene networksGenetic variant associationsMetabolic domainsMulti-level characterizationPhenome-wide associationAssociation studiesDrug-gene interactionsVariant associationsInteraction databasesGenesKey adhesion moleculeGenetic variantsPhenotype categoriesPotential involvementMiRNAsAdhesion moleculesPotential mechanismsRole of microbes in the pathogenesis of neuropsychiatric disorders
Goswami A, Wendt FR, Pathak GA, Tylee DS, De Angelis F, De Lillo A, Polimanti R. Role of microbes in the pathogenesis of neuropsychiatric disorders. Frontiers In Neuroendocrinology 2021, 62: 100917. PMID: 33957173, PMCID: PMC8364482, DOI: 10.1016/j.yfrne.2021.100917.Peer-Reviewed Original ResearchConceptsNeuropsychiatric disordersDifferent anatomical sitesOral cavityAnatomical sitesHuman studiesBody sitesTranslational potentialPotential involvementPathogenesisGutMicrobial metabolitesDisordersBidirectional communicationStrong evidenceDiseaseNeurotransmittersBrainMicrobiome researchMicrobiome variation