2024
Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls
Arya R, Kumar S, Vinetz J, Kim J, Chaurasia R. Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls. Expert Reviews In Molecular Medicine 2024, 26: e32. PMID: 39639643, PMCID: PMC11629464, DOI: 10.1017/erm.2024.29.Peer-Reviewed Original ResearchConceptsDisease stageHIV co-infectionAnti-TB therapyPotential of miRNAsInfectious diseasesPulmonary TBPulmonary tuberculosisActive TBFalse-positive outcomesTB diagnosticsDisease progressionLack of specificityPrognostic signatureCo-infectionLethal infectious diseaseDeadliest infectious diseasesPoint-of-care testingTuberculosisDiagnostic biomarkersStandard protocolDiseaseBiomarkersGene expressionNon-invasiveRegulatory role
2022
Comparison of the PF07598-Encoded Virulence-Modifying Proteins of L. interrogans and L. borgpetersenii
Vieira D, Chaurasia R, Vinetz J. Comparison of the PF07598-Encoded Virulence-Modifying Proteins of L. interrogans and L. borgpetersenii. Tropical Medicine And Infectious Disease 2022, 8: 14. PMID: 36668921, PMCID: PMC9863803, DOI: 10.3390/tropicalmed8010014.Peer-Reviewed Original ResearchVM proteinsEukaryotic cellsGene familyEnvironmental nichesDifferent cladesMammalian hostsSeverity of outbreaksVirulence effectsCellular pathogenesisHuman pathogensMediated TransmissionLeptospiral speciesParalogsPathogenic groupsProteinVaccine-mediated preventionSpeciesL. interrogansL. borgpeterseniiProtein exotoxinsNew strainFatal leptospirosisTarget cellsLeptospirosis pathogenesisInfectious diseases
2018
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue
Chaurasia R, Thresiamma K, Eapen C, Zachariah B, Paul R, Sritharan M. Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. European Journal Of Clinical Microbiology & Infectious Diseases 2018, 37: 423-433. PMID: 29332210, DOI: 10.1007/s10096-018-3187-9.Peer-Reviewed Original ResearchConceptsMicroscopic agglutination testAnti-leptospiral antibodiesEnzyme-linked immunosorbent assayLeptospiral antigensDifferential diagnosisGroup I patientsUrine of patientsPUO patientsI patientsUrinary antigenClinical symptomsDengue patientsNon-invasive methodStudy groupPatientsHigh titresDengue feverAgglutination testUnknown originInfectious diseasesAntigenDiagnosisImmunosorbent assayUrine samplesSpecific antibodies
2017
Proteinuria in early detection of human leptospirosis
Thresiamma K, Biju A, Chaurasia R, Sritharan M, Jayaprakash C, Thomas S, Eapen C. Proteinuria in early detection of human leptospirosis. International Journal Of Research In Medical Sciences 2017, 5: 646-652. DOI: 10.18203/2320-6012.ijrms20170168.Peer-Reviewed Original ResearchSymptoms of leptospirosisDay of admissionUrine samplesSerum antibodiesIgG classSame antigenELISA testStage of illnessCases of leptospirosisPresence of immunoglobulinAnti-leptospiral antibodiesRapid diagnostic testsFebrile illnessOptimal treatmentClinical signsPatient managementSignificant diagnostic potentialFrequent abnormalityHuman leptospirosisPatientsUrine concentratesClinical diagnosisInfectious diseasesELISA methodLeptospirosis