2024
Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis
Chaurasia R, Kamaraju S, Thresiamma K, Jayaprakash C, Eapen C, Sritharan M. Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis. Diagnostic Microbiology And Infectious Disease 2024, 111: 116647. PMID: 39671978, DOI: 10.1016/j.diagmicrobio.2024.116647.Peer-Reviewed Original ResearchGroup IPatients co-infectedDiagnostic potentialAnti-leptospiral antibodiesLeptospiral antigensPrognostic potentialRenal damageUrinary excretionClinical evaluationGroup IIUrinary proteinGroup IIIPatientsHuman patientsDiagnostic markerCirculating proteinsEndemic regionsAntigenAntibodiesProteinuriaCoinfectionImmunoblot analysisSerumUrineNon-invasive
2020
Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells.
Chaurasia R, Sritharan M. Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells. Microbiology 2020, 166: 1065-1073. PMID: 32985970, DOI: 10.1099/mic.0.000976.Peer-Reviewed Original ResearchConceptsVero cellsSerovar PomonaHaemorrhagic manifestationsHost cell damageEarly diagnosisSevere formHuman patientsExperimental animalsLeptospira interrogansLeptospirosisCandidate markersSphingomyelinase activityHaemolytic activityPomonaSphingomyelinasePathogenic membersCytotoxicitySphingomyelinase geneActive formHigh levelsCellsPatientsDiagnosisConfocal imagesSphingomyelinases