Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls
Arya R, Kumar S, Vinetz J, Kim J, Chaurasia R. Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls. Expert Reviews In Molecular Medicine 2024, 26: e32. PMID: 39639643, PMCID: PMC11629464, DOI: 10.1017/erm.2024.29.Peer-Reviewed Original ResearchConceptsDisease stageHIV co-infectionAnti-TB therapyPotential of miRNAsInfectious diseasesPulmonary TBPulmonary tuberculosisActive TBFalse-positive outcomesTB diagnosticsDisease progressionLack of specificityPrognostic signatureCo-infectionLethal infectious diseaseDeadliest infectious diseasesPoint-of-care testingTuberculosisDiagnostic biomarkersStandard protocolDiseaseBiomarkersGene expressionNon-invasiveRegulatory roleExploring the Role of Extracellular Vesicles in the Pathogenesis of Tuberculosis
Arya R, Shakya H, Chaurasia R, Haque A, Kim J. Exploring the Role of Extracellular Vesicles in the Pathogenesis of Tuberculosis. Genes 2024, 15: 434. PMID: 38674369, PMCID: PMC11049626, DOI: 10.3390/genes15040434.Peer-Reviewed Original ResearchConceptsProtein-protein interaction networkRNA-seq datasetsExtracellular vesiclesTB patientsHealthy controlsResponse regulatorCellular processesInteraction networkPathogenesis of tuberculosisExosome biogenesisImmune response regulationImmune cell profilesDEGsPotential biomarkersVAMP5Immune cell infiltration analysisGenesTherapeutic targetImmune cellsGlobal health concernDiagnostic performanceVesiclesDisease progressionTreatment outcomesAccurate diagnosis