2024
Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis
Chaurasia R, Kamaraju S, Thresiamma K, Jayaprakash C, Eapen C, Sritharan M. Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis. Diagnostic Microbiology And Infectious Disease 2024, 111: 116647. PMID: 39671978, DOI: 10.1016/j.diagmicrobio.2024.116647.Peer-Reviewed Original ResearchGroup IPatients co-infectedDiagnostic potentialAnti-leptospiral antibodiesLeptospiral antigensPrognostic potentialRenal damageUrinary excretionClinical evaluationGroup IIUrinary proteinGroup IIIPatientsHuman patientsDiagnostic markerCirculating proteinsEndemic regionsAntigenAntibodiesProteinuriaCoinfectionImmunoblot analysisSerumUrineNon-invasive
2018
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue
Chaurasia R, Thresiamma K, Eapen C, Zachariah B, Paul R, Sritharan M. Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. European Journal Of Clinical Microbiology & Infectious Diseases 2018, 37: 423-433. PMID: 29332210, DOI: 10.1007/s10096-018-3187-9.Peer-Reviewed Original ResearchConceptsMicroscopic agglutination testAnti-leptospiral antibodiesEnzyme-linked immunosorbent assayLeptospiral antigensDifferential diagnosisGroup I patientsUrine of patientsPUO patientsI patientsUrinary antigenClinical symptomsDengue patientsNon-invasive methodStudy groupPatientsHigh titresDengue feverAgglutination testUnknown originInfectious diseasesAntigenDiagnosisImmunosorbent assayUrine samplesSpecific antibodies
2014
Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis
Sritharan N, Choudhury M, Sivakolundu S, Chaurasia R, Chouhan N, Rao P, Sritharan M. Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis. European Journal Of Clinical Microbiology & Infectious Diseases 2014, 34: 33-40. PMID: 25037869, DOI: 10.1007/s10096-014-2203-y.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayTB patientsExtrapulmonary tuberculosisPulmonary tuberculosisHealthy controlsMycobacterium tuberculosisExtrapulmonary TB patientsNormal healthy controlsRecurrent tuberculosisHousehold contactsSerum ironEnhanced immunoreactivityTuberculosisImmunoreactive antibodyAntigenic fragmentsPatientsImmunosorbent assayM. tuberculosisDiagnostic potentialSerumAntigenAntibodiesNegative correlationNegligible levelsHigh levels