2024
Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis
Chaurasia R, Kamaraju S, Thresiamma K, Jayaprakash C, Eapen C, Sritharan M. Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis. Diagnostic Microbiology And Infectious Disease 2024, 111: 116647. PMID: 39671978, DOI: 10.1016/j.diagmicrobio.2024.116647.Peer-Reviewed Original ResearchGroup IPatients co-infectedDiagnostic potentialAnti-leptospiral antibodiesLeptospiral antigensPrognostic potentialRenal damageUrinary excretionClinical evaluationGroup IIUrinary proteinGroup IIIPatientsHuman patientsDiagnostic markerCirculating proteinsEndemic regionsAntigenAntibodiesProteinuriaCoinfectionImmunoblot analysisSerumUrineNon-invasive
2018
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue
Chaurasia R, Thresiamma K, Eapen C, Zachariah B, Paul R, Sritharan M. Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. European Journal Of Clinical Microbiology & Infectious Diseases 2018, 37: 423-433. PMID: 29332210, DOI: 10.1007/s10096-018-3187-9.Peer-Reviewed Original ResearchConceptsMicroscopic agglutination testAnti-leptospiral antibodiesEnzyme-linked immunosorbent assayLeptospiral antigensDifferential diagnosisGroup I patientsUrine of patientsPUO patientsI patientsUrinary antigenClinical symptomsDengue patientsNon-invasive methodStudy groupPatientsHigh titresDengue feverAgglutination testUnknown originInfectious diseasesAntigenDiagnosisImmunosorbent assayUrine samplesSpecific antibodies
2017
Proteinuria in early detection of human leptospirosis
Thresiamma K, Biju A, Chaurasia R, Sritharan M, Jayaprakash C, Thomas S, Eapen C. Proteinuria in early detection of human leptospirosis. International Journal Of Research In Medical Sciences 2017, 5: 646-652. DOI: 10.18203/2320-6012.ijrms20170168.Peer-Reviewed Original ResearchSymptoms of leptospirosisDay of admissionUrine samplesSerum antibodiesIgG classSame antigenELISA testStage of illnessCases of leptospirosisPresence of immunoglobulinAnti-leptospiral antibodiesRapid diagnostic testsFebrile illnessOptimal treatmentClinical signsPatient managementSignificant diagnostic potentialFrequent abnormalityHuman leptospirosisPatientsUrine concentratesClinical diagnosisInfectious diseasesELISA methodLeptospirosis