Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
Schwam D, Luciano R, Mahajan S, Wong L, Wilson A. Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies. Journal Of Virology 2000, 74: 8532-8540. PMID: 10954554, PMCID: PMC116365, DOI: 10.1128/jvi.74.18.8532-8540.2000.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, ViralCell LineCell NucleusConserved SequenceDimerizationGene Expression Regulation, ViralGenes, ReporterHerpesvirus 8, HumanHumansImmunoblottingLuciferasesMicroscopy, FluorescenceMolecular Sequence DataNuclear ProteinsSequence AlignmentTranscription, GeneticVirionConceptsLatency-associated nuclear antigenC-terminusHeterologous DNA-binding domainDNA-binding domainForms stable dimersPotent transcriptional repressorViral lytic genesC-terminal regionSeries of truncationsHigher-order multimersViral gene expressionNuclear specklesSubnuclear specklesTranscriptional repressionTranscriptional repressorCellular genesCertain B-cell lymphomasNuclear bodiesActive promotersCarboxy terminusGene expressionCell immortalizationFunctional similarityViral episomesIntact protein